Letra A, Menezes R, Granjeiro J M, Vieira A R
Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, 614 Salk Hall, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA.
J Dent Res. 2007 Oct;86(10):986-91. doi: 10.1177/154405910708601013.
Individuals with clefts present considerably more dental anomalies than do individuals without clefts. We used dental development to subphenotype clefts with the goal of identifying cleft subgroups that could have specific genetic contributions. We examined 1000 individuals, 500 with clefts and 500 without. We used several clinical features, such as cleft completeness or incompleteness, laterality, and the presence of dental anomalies to assess each individual's cleft status. We performed chi-square and Fisher's exact tests to compare the frequencies of observed anomalies between individuals with and individuals without clefts, and among individuals with different cleft subphenotypes. Agenesis of the lateral incisor on the non-cleft side was the most remarkable observation, and may suggest that such cases could be considered incomplete forms of bilateral clefts of the lip.
患有腭裂的个体比未患腭裂的个体出现更多的牙齿异常。我们利用牙齿发育情况对腭裂进行亚分型，目的是识别可能有特定基因贡献的腭裂亚组。我们检查了1000名个体，其中500名患有腭裂，500名未患腭裂。我们使用了几种临床特征，如腭裂的完全性或不完全性、侧别以及牙齿异常的存在情况来评估每个个体的腭裂状态。我们进行了卡方检验和费舍尔精确检验，以比较患腭裂个体与未患腭裂个体之间以及不同腭裂亚分型个体之间观察到的异常频率。非腭裂侧侧切牙缺失是最显著的观察结果，这可能表明此类病例可被视为双侧唇裂的不完全形式。
