El-Hennawy Adel S, Nesa Mushammat, Mahmood Aza K
Nephrology and Dialysis Center, Department of Medicine, Renal Division, Coney Island Hospital, Brooklyn, NY, USA.
Am J Ther. 2007 Sep-Oct;14(5):499-501. doi: 10.1097/MJT.0b013e31814daf53.
Thyrotoxic hypokalemic periodic paralysis is an uncommon disorder characterized by elevated thyroid hormone, muscle weakness or paralysis, and intracellular shifts of potassium leading to hypokalemia. This article presents a case of thyrotoxic hypokalemic periodic paralysis in a 22-year old Hispanic man with nonfamilial thyrotoxic hypokalemic periodic paralysis triggered by a high carbohydrate diet. Laboratory studies showed elevated thyroid hormone, decreased thyroid-stimulating hormone, and hypokalemia. Rapid reduction in thyroid hormone levels by giving antithyroid drugs such as propylthiouracil and prompt potassium therapy with frequent measurements of serum potassium levels during therapy to avoid catastrophic hyperkalemia when potassium starts to shift back from intracellular to extracellular compartments can lead to successful outcome.
甲状腺毒症性低钾性周期性麻痹是一种罕见的疾病，其特征为甲状腺激素升高、肌肉无力或麻痹，以及钾离子向细胞内转移导致低钾血症。本文介绍了一例22岁西班牙裔男性的甲状腺毒症性低钾性周期性麻痹病例，该患者为非家族性甲状腺毒症性低钾性周期性麻痹，由高碳水化合物饮食诱发。实验室检查显示甲状腺激素升高、促甲状腺激素降低和低钾血症。通过给予丙硫氧嘧啶等抗甲状腺药物迅速降低甲状腺激素水平，并在治疗期间及时进行钾治疗并频繁测量血清钾水平，以避免钾开始从细胞内向细胞外转移时发生灾难性高钾血症，可取得成功的治疗效果。
