Guo D A, Lou Z C, Gao C Y, Qiao L, Peng J R
School of Pharmaceutical Sciences, Beijing Medical University.
Yao Xue Xue Bao. 1991;26(6):442-6.
Three phytoecdysteroids I, II and III were isolated from the root of Rhaponticum uniflorum (L.) DC. and their structures were elucidated by chemical and spectroscopic methods (UV, IR, EI-MS, FAB-MS, 1HNMR, 13CNMR, 1H-1H COSY, 1H-1H NOESY, 1H-13CCOSY and CD). Compound II is new and named rhapontisterone, its structure was confirmed as (20R, 22R, 24S)-2 beta, 3 beta, 11 alpha, 14 alpha, 20, 22, 24-heptahydroxy-5 beta cholest-7-en-6-one. The other two, I and III, were identified as ecdysterone and turkesterone, respectively, both are known compounds, but turkesterone was isolated for the first time from the title plant.
从祁州漏芦（Rhaponticum uniflorum (L.) DC.）的根部分离出三种植物蜕皮甾体I、II和III，并通过化学和光谱方法（紫外光谱、红外光谱、电子轰击质谱、快原子轰击质谱、核磁共振氢谱、核磁共振碳谱、氢-氢化学位移相关谱、氢-氢核欧沃豪斯效应谱、氢-碳化学位移相关谱和圆二色光谱）阐明了它们的结构。化合物II是新化合物，命名为漏芦甾酮，其结构确定为(20R, 22R, 24S)-2β, 3β, 11α, 14α, 20, 22, 24-七羟基-5β-胆甾-7-烯-6-酮。另外两种化合物I和III分别鉴定为蜕皮甾酮和土克甾酮，二者均为已知化合物，但土克甾酮是首次从该植物中分离得到。
