[甘草皂苷的结构]

[The structure of glyeurysaponin].

作者信息

Cai L N, Zhang R Y, Zhang Z L, Wang B, Qiao L, Huang L R, Cheng J R

机构信息

School of Pharmaceutical Science, Beijing Medical University.

出版信息

Yao Xue Xue Bao. 1991;26(6):447-50.

PMID:1789112

Abstract

A species of the genus Glycyrrhiza, G. eurycarpa P.C. Li recently reported as a new species growing in Gansu Province Xinjiang Autonomous Region has rarely been studied before on its chemical constituents. This paper reports the isolation and chemical elucidation of two triterpene glucosides named glyeurysaponin (K-4) and uralsaponin B (K-3) from this species collected in Jinta County, Gansu Province. Their chemical structures were elucidated by means of chemical and spectrometric analysis (UV, IR, MS, 1HNMR and 13CNMR) and were first reported to be present in this plant. Glyeurysaponin (K-4), C42H62O16 was obtained as white crystals, mp 288 degrees C (d), [alpha]18D + 22.5 degrees (c 0.62,60%MeOH). Its structure was found to be be 3 beta-hydroxy-11-oxo-olean-12-en-30-oic acid-3-O-beta-D-glucuronopyranosyl-(1----4)-beta-D-glucuronopyr anoside. Glyeurysaponin is a new triterpenoid saponin. The known saponin was identified to be 3 beta-hydroxy-11-oxo-olean-12-en-30-oic acid-3-O-beta-D-glucuronopyranosyl-(1----3)-beta-D-glucuronopyr anoside, uralsaponin B.

摘要

甘草属的一个物种，即最近报道生长于甘肃省和新疆自治区的宽果甘草，此前对其化学成分的研究很少。本文报道了从采自甘肃省金塔县的该物种中分离得到两种三萜糖苷——甘草皂苷（K - 4）和乌拉尔甘草皂苷B（K - 3），并对其进行了化学结构解析。通过化学和光谱分析（紫外、红外、质谱、1H核磁共振和13C核磁共振）阐明了它们的化学结构，且首次报道它们存在于该植物中。甘草皂苷（K - 4），C42H62O16，为白色晶体，熔点288℃（分解），[α]18D + 22.5°（c 0.62，60%甲醇）。其结构为3β - 羟基 - 11 - 氧代 - 齐墩果 - 12 - 烯 - 30 - 酸 - 3 - O - β - D - 葡萄糖醛酸吡喃糖基 - (1→4) - β - D - 葡萄糖醛酸吡喃糖苷。甘草皂苷是一种新的三萜类皂苷。已知皂苷被鉴定为3β - 羟基 - 11 - 氧代 - 齐墩果 - 12 - 烯 - 30 - 酸 - 3 - O - β - D - 葡萄糖醛酸吡喃糖基 - (1→3) - β - D - 葡萄糖醛酸吡喃糖苷，即乌拉尔甘草皂苷B。