日本五加叶的三萜皂苷

Triterpenoid saponins of Acanthopanax nipponicus leaves.

作者信息

Miyakoshi M, Shirasuna K, Hirai Y, Shingu K, Isoda S, Shoji J, Ida Y, Shimizu T

机构信息

School of Pharmaceutical Sciences, Showa University, Hatanodai 1-5-8, Shinagawa-ku, Tokyo 142-8555, Japan.

出版信息

J Nat Prod. 1999 Mar;62(3):445-8. doi: 10.1021/np9804334.

DOI:10.1021/np9804334

PMID:10096855

Abstract

Five new triterpenoid saponins, nipponosides A-E (1, 3-6), were isolated from Acanthopanax nipponicus leaves, along with a known saponin, kalopanaxsaponin G (2). Nipponosides A-E were characterized as the 28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->6)-beta -D-glucopyranosyl ester of 3-oxohederagenin, oleanolic acid 3-O-beta-D-glucopyranoside, gypsogenin 3-O-beta-D-glucopyranoside, 3beta,23,29-trihydroxyolean-12-en-28-oic acid, and 3beta,20alpha, 23-trihydroxy-30-nor-olean-12-en-28-oic acid, respectively. The structures of these new compounds were based on chemical and spectral methods.

摘要

从辽东楤木叶中分离出5种新的三萜皂苷，即辽东楤木皂苷A - E（1, 3 - 6），以及一种已知皂苷，刺楸皂苷G（2）。辽东楤木皂苷A - E分别被鉴定为3 - 氧代齐墩果酸的28 - O-α-L-鼠李吡喃糖基（1→4）-β-D-吡喃葡萄糖基（1→6）-β-D-吡喃葡萄糖基酯、齐墩果酸3 - O-β-D-吡喃葡萄糖苷、绞股蓝皂苷元3 - O-β-D-吡喃葡萄糖苷、3β,23,29 - 三羟基齐墩果-12 - 烯-28 - 酸和3β,20α,23 - 三羟基-30 - 去甲齐墩果-12 - 烯-28 - 酸。这些新化合物的结构通过化学和光谱方法确定。