伊朗东南部健康儿童中抗幽门螺杆菌和抗细胞毒素相关基因A（CagA）抗体的血清流行率与年龄、性别、ABO血型及Rh血型的关系
Seroprevalence of anti-Helicobacter pylori and anti-CagA antibodies among healthy children according to age, sex, ABO blood groups and Rh status in south-east of Iran.
作者信息
Jafarzadeh Abdollah, Ahmedi-Kahanali Jafar, Bahrami Mehdi, Taghipour Zahra
机构信息
Rafsanjan University of Medical Sciences, School of Medicine, Department of Immunology, Rafsanjan, Iran.
出版信息
Turk J Gastroenterol. 2007 Sep;18(3):165-71.
OBJECTIVE
The aim of this study was to evaluate the seroprevalence of anti-H. pylori and anti-CagA antibodies in healthy children and to investigate those relation with age, sex, ABO blood groups and Rh status.
METHODS
Serum samples from 386 children (187 males; 199 females), aged 1-15 years were tested for the presence of antibody to H. pylori and its virulence factor (CagA) by use of ELISA. ABO blood grouping were also done by hemagglutination test .
RESULTS
The overall seroprevalence of H. pylori infection was 46.6%. The prevalence of anti-H. pylori antibody was significantly (p<0.05) higher in males (51.9%) compare to females (41.7%). The prevalence of anti-CagA antibody in infected children was 72.8%. Although, the prevalence of anti-CagA antibody was higher in males (78.4%) compared to females (66.3%), but the difference was not statistically significant (p=0.07). In age subgroups of 1-5 years, 6-10 years and 11-15 years, the prevalence of anti-H. pylori was 37.6%, 46.9% and 54.9% and regarding infected-children the prevalence and the mean titer of anti-CagA antibody were 63.8%, 75.94 Uarb/ml; 75%, 63.32 Uarb/ml and 79.45%, 57.11 Uarb/ml; respectively. The seroprevalence of anti-H. pylori and anti-CagA (in infected children) were 53% and 77.3% in blood group A, 50.5% and 64.7% in blood group B, 44.4% and 62.5% in blood group AB, 41.6 % and 76.8% in blood group O, 45.9% and 73% in Rh(+) phenotype and 54.84% and 70.6% in Rh(-) phenotype, respectively. The prevalence of both antibodies did not significantly differ between ABO blood groups or Rh status. However, within blood group A, the prevalence of anti-H. pylori and anti-CagA was significantly higher in males compare to females (p<0.05).
CONCLUSION
These results showed that almost half of the children acquire H. pylori infection. Anti-CagA antibody are also common in the children. The seroprevalence of anti-H. pylori and anti-CagA antibodies were higher in males and increased with age. However, the mean titer of anti-CagA antibodies decreased with age, inversely. ABO blood groups may partly influence the prevalence of H. pylori infection, especially in male gender.
目的
本研究旨在评估健康儿童中抗幽门螺杆菌（H. pylori）和抗细胞毒素相关基因A（CagA）抗体的血清流行率，并探讨其与年龄、性别、ABO血型及Rh血型的关系。
方法
采用酶联免疫吸附测定（ELISA）法检测386名1至15岁儿童（187名男性；199名女性）血清样本中抗H. pylori抗体及其毒力因子（CagA）抗体。同时采用血凝试验进行ABO血型鉴定。
结果
H. pylori感染的总体血清流行率为46.6%。男性抗H. pylori抗体流行率（51.9%）显著高于女性（41.7%）（p<0.05）。感染儿童中抗CagA抗体流行率为72.8%。虽然男性抗CagA抗体流行率（78.4%）高于女性（66.3%），但差异无统计学意义（p = 0.07）。在1至5岁、6至10岁和11至15岁年龄亚组中，抗H. pylori流行率分别为37.6%、46.9%和54.9%；在感染儿童中，抗CagA抗体流行率及平均滴度分别为63.8%、75.94 Uarb/ml；75%、63.32 Uarb/ml；79.45%、57.11 Uarb/ml。A、B、AB、O血型儿童抗H. pylori血清流行率分别为53%、50.5%、44.4%、41.6%，抗CagA（感染儿童中）血清流行率分别为77.3%、64.7%、62.5%、76.8%；Rh(+)和Rh(-)血型儿童抗H. pylori血清流行率分别为45.9%、54.84%，抗CagA（感染儿童中）血清流行率分别为73%、70.6%。两种抗体在ABO血型或Rh血型间流行率差异均无统计学意义。然而，在A型血儿童中，男性抗H. pylori和抗CagA流行率显著高于女性（p<0.05）。
结论
这些结果表明，近一半儿童感染H. pylori。抗CagA抗体在儿童中也很常见。抗H. pylori和抗CagA抗体血清流行率男性高于女性，且随年龄增加。然而，抗CagA抗体平均滴度随年龄呈相反降低。ABO血型可能部分影响H. pylori感染流行率，尤其在男性中。
Zotero 插件