Pham L, Woelk G B, Ning Y, Madzime S, Mudzamiri S, Mahomed K, Williams M A
Department of Epidemiology ,University of Washington School of Public Health and Community Medicine, Seattle, USA.
Cent Afr J Med. 2005 Mar-Apr;51(3-4):24-30.
To evaluate risk factors and outcomes of syphilis during pregnancy.
Hospital based, cross sectional study.
Harare Maternity Hospital, Harare, Zimbabwe.
A random sample of 2 969 pregnant women.
Syphilis seroprevalence.
Of the 2 969 women who provided blood samples, 4.8% were RPR positive. Approximately 2.2% of study subjects were RPR positive and TPHA negative. Notably, 2.5% of the population was RPR and TPHA positive at the time of giving birth. Older women had a higher risk of having positive syphilis status (p = 0.057). Increases in parity and gravidity were significantly associated with increased risk of syphilis infection. Prior stillbirths were associated with an increased risk of syphilis infection (odds ratio [OR], 3.4; 95% CI, 1.61 to 7.37; p = 0.001). Syphilis positive mothers were significantly more likely to give birth to syphilis positive newborns (p < 0.0001).
Our results suggest that there should be more effective antenatal screening and treatment of syphilis in Harare. Syphilis affects many sub-Saharan countries where effective educational outreach, screening, and treatment should take place to prevent the transmission of this venereal disease, especially among reproductive age and pregnant women.
评估孕期梅毒的危险因素及结局。
基于医院的横断面研究。
津巴布韦哈拉雷的哈拉雷妇产医院。
2969名孕妇的随机样本。
梅毒血清阳性率。
在提供血样的2969名女性中，4.8%的人快速血浆反应素环状卡片试验（RPR）呈阳性。约2.2%的研究对象RPR呈阳性但梅毒螺旋体血球凝集试验（TPHA）呈阴性。值得注意的是，2.5%的人群在分娩时RPR和TPHA均呈阳性。年龄较大的女性梅毒检测呈阳性的风险更高（p = 0.057）。产次和妊娠次数的增加与梅毒感染风险的增加显著相关。既往死产与梅毒感染风险增加相关（优势比[OR]，3.4；95%置信区间，1.61至7.37；p = 0.001）。梅毒检测呈阳性的母亲生出梅毒检测呈阳性的新生儿的可能性显著更高（p < 0.0001）。
我们的结果表明，哈拉雷应加强梅毒的产前筛查和治疗。梅毒影响许多撒哈拉以南国家，在这些国家应开展有效的教育宣传、筛查和治疗，以预防这种性病的传播，尤其是在育龄妇女和孕妇中。
