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津巴布韦穆雷瓦区的梅毒:一个持续肆虐的老问题。

Syphilis in Murewa District, Zimbabwe: an old problem that rages on.

作者信息

Kambarami R A, Manyame B, Macq J

机构信息

UNICEF, Belgravia, Harare, Zimbabwe.

出版信息

Cent Afr J Med. 1998 Sep;44(9):229-32.

PMID:10101428
Abstract

OBJECTIVE

To determine the prevalence of syphilis among pregnant women and women giving birth in health centres in a rural district and to identify problems associate with syphilis control in the same district.

DESIGN

Cross sectional descriptive study.

SETTING

Murewa District health facilities.

SUBJECTS

Women attending health facilities in this district for antenatal care or delivery between February and May 1993.

MAIN OUTCOME MEASURES

Syphilis sero-prevalence rate. Factors associated with poor syphilis control.

RESULTS

Even though it is recommended that all women attending clinics for antenatal care (ANC) should be screened for syphilis at first visit only 308 (20%) out of 1,556 first visit attenders were screened during the study period. Three hundred and sixty six (33%) out of 1,096 women giving birth in health institutions were screened. The RPR/TPHA sero positivity rate for antenatal women was 9.2% while that for women delivering was 9.8%. A positive RPR was not significantly associated with the women's age, parity, infant's birth weight, sex or pregnancy outcome. Factors associated with poor syphilis control in this district included: lack of motivation and appreciation of the seriousness of syphilis in pregnancy; lack of transport to send specimens and receive results from Murewa District Hospital; poor record keeping; loss to follow up of women being tested or after starting treatment; lack of contact tracing and treatment of contacts and difficulties in implementing the 10 day neonatal regime and follow up of these infants.

CONCLUSION

Syphilis remains poorly controlled in Murewa district and may be contributing significantly to high perinatal mortality rates. There is need to strengthen the syphilis control programme through motivation and training of health workers, decentralisation of testing and treatment of the condition and improved contact tracing. A repeat RPR test at delivery may not be cost effective.

摘要

目的

确定农村地区健康中心的孕妇及产妇梅毒感染率,并找出该地区梅毒防控相关问题。

设计

横断面描述性研究。

地点

穆雷瓦区卫生设施。

研究对象

1993年2月至5月间在该地区卫生设施接受产前检查或分娩的妇女。

主要观察指标

梅毒血清感染率。梅毒防控不力的相关因素。

结果

尽管建议所有前来产前检查门诊的妇女在首次就诊时都应接受梅毒筛查,但在研究期间,1556名首次就诊者中仅有308人(20%)接受了筛查。在医疗机构分娩的1096名妇女中有366人(33%)接受了筛查。产前妇女的快速血浆反应素环状卡片试验(RPR)/梅毒螺旋体血球凝集试验(TPHA)血清阳性率为9.2%,而产妇的该阳性率为9.8%。RPR阳性与妇女年龄、胎次、婴儿出生体重、性别或妊娠结局无显著关联。该地区梅毒防控不力的相关因素包括:对孕期梅毒严重性缺乏认识和重视;缺乏运送标本及从穆雷瓦区医院获取结果的交通条件;记录保存不善;检测或开始治疗后的妇女失访;缺乏性伴追踪及性伴治疗;实施10天新生儿方案及对这些婴儿的随访存在困难。

结论

穆雷瓦区梅毒防控状况仍然不佳,可能是导致围产儿死亡率高的重要原因。需要通过激励和培训卫生工作者、将病情检测与治疗权力下放以及改善性伴追踪来加强梅毒防控项目。分娩时重复进行RPR检测可能不具有成本效益。

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