安杀霉素类：极性安莎霉素衍生物。

The ansacarbamitocins: polar ansamitocin derivatives.

作者信息

Snipes Carl E, Duebelbeis Dennis O, Olson Monica, Hahn Donald R, Dent William H, Gilbert Jeffrey R, Werk Todd L, Davis George E, Lee-Lu Rebecca, Graupner Paul R

机构信息

Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA.

出版信息

J Nat Prod. 2007 Oct;70(10):1578-81. doi: 10.1021/np070275t. Epub 2007 Sep 25.

DOI:10.1021/np070275t

PMID:17892263

Abstract

The ansacarbamitocins are a new family of maytansinoids that are unusually substituted with a glucose subunit and two carbamate functional groups and exhibit modest activity against some agricultural fungal disease organisms. Ansacarbamitocins A-F ( 1- 6) all consist of the same macrocyclic core as the ansamitocins, with variation occurring on the glucose unit, while ansacarbamitocins A1 and B1 ( 7, 8) additionally lack the epoxide group on C-4 and C-5.

摘要

安沙卡巴米托菌素是一类新的美登素类化合物，其独特之处在于带有一个葡萄糖亚基和两个氨基甲酸酯官能团，并且对一些农业真菌病原体表现出一定活性。安沙卡巴米托菌素A - F（1 - 6）与安丝菌素具有相同的大环核心结构，只是葡萄糖单元有所不同，而安沙卡巴米托菌素A1和B1（7, 8）在C - 4和C - 5位上还额外缺少环氧基团。