Stephens Geoffrey L, Shevach Ethan M
Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Immunity. 2007 Sep;27(3):417-9. doi: 10.1016/j.immuni.2007.08.008.
The Foxp3+ T cell lineage is thought to arise from self-specific precursors during development. By using a unique mouse model, Pacholczyk et al. (2007) present compelling evidence that self-specific cells are exceedingly rare among Foxp3(-) and, surprisingly, Foxp3+ subsets.
Foxp3+ T细胞谱系被认为在发育过程中源自自身特异性前体细胞。通过使用一种独特的小鼠模型，帕乔尔茨克等人（2007年）提供了令人信服的证据，表明自身特异性细胞在Foxp3(-)以及令人惊讶的是在Foxp3+亚群中极其罕见。
