French National Institute of Health and Medical Research, Paris Cardiovascular Research Center, Université Paris Descartes, 56 rue Leblanc, Paris, France.
Nat Rev Cardiol. 2011 Jun;8(6):348-58. doi: 10.1038/nrcardio.2011.62. Epub 2011 Apr 19.
Chronic inflammation drives the development of atherosclerosis, and adaptive immunity is deeply involved in this process. Initial studies attributed a pathogenic role to T cells in atherosclerosis, mainly owing to the proatherogenic role of the T-helper (T(H))-1 cell subset, whereas the influence of T(H)2 and T(H)17 subsets is still debated. Today we know that T regulatory cells play a critical role in the protection against atherosclerotic lesion development and inflammation. In contrast to T cells, B cells were initially considered to be protective in atherosclerosis, assumingly through the production of protective antibodies against oxidized LDL. This concept has now been refined and proatherogenic roles of certain mature B cell subsets have been identified. We review the current knowledge about the role of various lymphocyte subsets in the development and progression of atherosclerosis and highlight future targets for immunomodulatory therapy.
慢性炎症会导致动脉粥样硬化的发生，适应性免疫在这个过程中起着重要作用。早期研究认为 T 细胞在动脉粥样硬化中起致病作用，主要归因于辅助性 T 细胞（T helper，T(H))-1 亚群的促动脉粥样硬化作用，而 T(H)2 和 T(H)17 亚群的影响仍存在争议。如今我们知道，调节性 T 细胞在保护动脉粥样硬化损伤和炎症方面发挥着关键作用。与 T 细胞不同，B 细胞最初被认为在动脉粥样硬化中具有保护作用，可能是通过产生针对氧化型低密度脂蛋白的保护性抗体。这一概念现在已经得到了进一步的完善，某些成熟的 B 细胞亚群也被发现具有促动脉粥样硬化作用。我们综述了目前关于各种淋巴细胞亚群在动脉粥样硬化发生和进展中的作用的知识，并强调了免疫调节治疗的未来靶点。
