Medical Department I (Gastroenterology/Rheumatology/Infectious Diseases), Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany.
World J Gastroenterol. 2011 Jul 21;17(27):3178-83. doi: 10.3748/wjg.v17.i27.3178.
Inflammatory bowel diseases are the consequence of a dysregulated mucosal immune system. The mucosal immune system consists of two arms, innate and adaptive immunity, that have been studied separately for a long time. Functional studies from in vivo models of intestinal inflammation as well as results from genome-wide association studies strongly suggest a cross-regulation of both arms. The present review will illustrate this interaction by selecting examples from innate immunity and adaptive immunity, and their direct impact on each other. Broadening our view by focusing on the cross-regulated areas of the mucosal immune system will not only facilitate our understanding of disease, but furthermore will allow identification of future therapeutic targets.
炎症性肠病是黏膜免疫系统失调的结果。黏膜免疫系统由先天免疫和适应性免疫两个分支组成，这两个分支长期以来一直被分开研究。来自肠道炎症的体内模型的功能研究以及全基因组关联研究的结果强烈提示这两个分支存在相互调节。本综述将通过选择先天免疫和适应性免疫及其相互直接影响的例子来说明这种相互作用。通过关注黏膜免疫系统的交叉调节区域来拓宽我们的视野，不仅将有助于我们对疾病的理解，而且还将有助于确定未来的治疗靶点。
