Ding C, Martel-Pelletier J, Pelletier J-P, Abram F, Raynauld J-P, Cicuttini F, Jones G
Menzies Research Institute, University of Tasmania, Hobart, Australia.
Osteoarthritis Cartilage. 2008 Apr;16(4):443-9. doi: 10.1016/j.joca.2007.08.009. Epub 2007 Sep 24.
To identify factors associated with change in femoral cartilage volume over 2 years in a cohort largely without knee radiographic osteoarthritis.
A total of 252 subjects (mean 45 years, range 28-60) were used for this study. T1-weighted fat saturation magnetic resonance imaging was performed at baseline and approximately 2 years later. Knee femoral condyle cartilage volume, femoral cartilage defect (0-4 scale) and tibial bone size were determined.
The total femoral cartilage volume loss was 6.3% for the 2.3-year period. Factors associated with this annual change were female gender (females vs males: -1.69%, P<0.01), age (over vs under 40 years: -0.96%, P=0.01), smoking (beta: -0.04% per pack-years, P<0.01), as well as lower limb muscle strength (r: +0.32, P<0.01) and its change (beta: +0.34% per quartile, P<0.05). Structural factors associated with change included baseline femoral cartilage volume (beta: -0.36% per ml, P<0.01), femoral cartilage defects (beta: +1.07% per grade, P<0.01), tibial bone area (beta: +0.13% per cm(2), P<0.05), lateral osteophytes (beta: -1.91% per grade, P<0.01) and change in femoral cartilage defects (beta: -0.8% per grade, P<0.001).
This study provides evidence confirming that significant risk factors are associated with femoral cartilage loss and these include gender (female), age, smoking, and severity of lower limb muscle weakness. It also supports the hypothesis that femoral cartilage swelling reflected by an increased baseline cartilage volume could be a predictor of disease progression. Our findings also provide interesting clues to implement preventive measures that can possibly prevent or reduce knee cartilage loss.
在一个基本无膝关节影像学骨关节炎的队列中，确定与2年内股骨软骨体积变化相关的因素。
本研究共纳入252名受试者（平均45岁，范围28 - 60岁）。在基线时及大约2年后进行T1加权脂肪饱和磁共振成像。测定膝关节股骨髁软骨体积、股骨软骨缺损（0 - 4级）和胫骨骨大小。
在2.3年期间，股骨软骨总体积损失为6.3%。与这种年度变化相关的因素包括女性性别（女性与男性相比：-1.69%，P<0.01）、年龄（40岁以上与40岁以下相比：-0.96%，P = 0.01）、吸烟（β：每包年-0.04%，P<0.01），以及下肢肌肉力量（r：+0.32，P<0.01）及其变化（β：每四分位数+0.34%，P<0.05）。与变化相关的结构因素包括基线股骨软骨体积（β：每毫升-0.36%，P<0.01）、股骨软骨缺损（β：每级+1.07%，P<0.01）、胫骨骨面积（β：每平方厘米+0.13%，P<0.05）、外侧骨赘（β：每级-1.91%，P<0.01）和股骨软骨缺损的变化（β：每级-0.8%，P<0.001）。
本研究提供的证据证实，显著的风险因素与股骨软骨丢失相关，这些因素包括性别（女性）、年龄、吸烟和下肢肌肉无力的严重程度。它还支持这样的假设，即基线软骨体积增加所反映的股骨软骨肿胀可能是疾病进展的预测指标。我们的研究结果也为实施可能预防或减少膝关节软骨丢失的预防措施提供了有趣的线索。
