Lubrano E, D'Angelo S, Parsons W J, Corbi G, Ferrara N, Rengo F, Olivieri I
Rheumatology & Rehabilitation Research Unit, Maugeri Foundation IRCCS, Research Institute for Rehabilitative Medicine, Telese Terme (BN), 82037, Italy.
Rheumatology (Oxford). 2007 Nov;46(11):1672-5. doi: 10.1093/rheumatology/kem247. Epub 2007 Sep 24.
To assess the effectiveness of rehabilitation in a group of patients with active ankylosing spondylitis (AS) by the Assessment in Ankylosing Spondylitis (ASAS) Working Group response criteria.
Fifty-two active AS patients consecutively admitted to a rehabilitation inpatient clinic were enrolled. Patients underwent a 3-week intensive rehabilitation programme and were then discharged with home exercises. The primary outcome measure was the proportion of patients achieving a response based on ASAS 20 at discharge, and at 6 and 12 weeks after. Secondary outcome measures included an improvement in the Revised Leeds Disability Questionnaire (RLDQ) and function expressed as anthropometric measures.
The ASAS 20 was achieved in 46 patients (88.5%) at the end of the rehabilitation, in 31 (59.6%) and in 17 (32.7%) patients at 6 and 12 weeks follow-up, respectively. The percentage of ASAS 20 responders statistically declined over time measured from the end of rehabilitation compared with 6 (P < 0.001) and 12 weeks follow-up (P < 0.001).
The present study shows the effectiveness of rehabilitation as assessed by the ASAS 20, a validated instrument for treatment response, suggesting its usage in rehabilitation settings. Moreover, the results obtained show that the effectiveness of the intensive inpatient rehabilitation declined over time.
根据强直性脊柱炎评估（ASAS）工作组反应标准，评估康复治疗对一组活动期强直性脊柱炎（AS）患者的疗效。
连续纳入52例入住康复住院诊所的活动期AS患者。患者接受为期3周的强化康复计划，然后出院并进行家庭锻炼。主要结局指标是出院时、出院后6周和12周时达到ASAS 20反应的患者比例。次要结局指标包括修订的利兹残疾问卷（RLDQ）的改善情况以及以人体测量指标表示的功能改善情况。
康复结束时，46例患者（88.5%）达到ASAS 20，6周和12周随访时分别有31例（59.6%）和17例（32.7%）患者达到ASAS 20。与6周（P < 0.001）和12周随访（P < 0.001）相比，从康复结束开始测量，ASAS 20反应者的百分比随时间推移在统计学上有所下降。
本研究表明，通过ASAS 20评估的康复治疗是有效的，ASAS 20是一种用于评估治疗反应的有效工具，提示其可用于康复治疗环境。此外，获得的结果表明，强化住院康复治疗的效果随时间推移而下降。
