Day N L, Goldschmidt L, Robles N, Richardson G, Cornelius M, Taylor P, Geva D, Stoffer D
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213-2593.
Alcohol Clin Exp Res. 1991 Dec;15(6):914-8. doi: 10.1111/j.1530-0277.1991.tb05187.x.
This is an analysis of the effect of prenatal alcohol exposure on growth of the offspring at 18 months of age. In this prospective study, a cohort of women was interviewed at the end of each trimester of pregnancy, at delivery, and at 8 and 18 months. Offspring were examined at each follow-up point. Two drinking scales, average daily volume (ADV) and frequent heavy drinking (FHD), were used to explore the effect of different patterns of drinking. We found significant relationships between both prenatal FHD and ADV and offspring growth at 18 months. A significant and inverse relationship was found between ADV during the second and the third trimesters of pregnancy and weight, height, and head circumference at 18 months. Frequent heavy drinking during all three trimesters predicted a significant decrease in head circumference at 18 months. FHD during the second trimester was significantly related to weight and height at 18 months. Analyses demonstrated that ADV was a better predictor of growth deficits than FHD.
这是一项关于产前酒精暴露对18个月大后代生长影响的分析。在这项前瞻性研究中，一组女性在孕期的每个 trimester 末、分娩时以及8个月和18个月时接受访谈。在每个随访点对后代进行检查。使用了两种饮酒量表，即平均日饮酒量（ADV）和频繁大量饮酒（FHD），以探讨不同饮酒模式的影响。我们发现产前FHD和ADV与18个月时后代的生长之间均存在显著关系。在妊娠的第二和第三个 trimester 期间的ADV与18个月时的体重、身高和头围之间存在显著的负相关关系。在所有三个 trimester 期间频繁大量饮酒预示着18个月时头围会显著减小。妊娠第二个 trimester 期间的FHD与18个月时的体重和身高显著相关。分析表明，ADV比FHD更能预测生长缺陷。
