Sampson P D, Bookstein F L, Barr H M, Streissguth A P
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle 98195.
Am J Public Health. 1994 Sep;84(9):1421-8. doi: 10.2105/ajph.84.9.1421.
The purpose of the study was to examine the effect of prenatal alcohol exposure on offspring's weight, height, and head circumference from birth through 14 years of age.
This longitudinal prospective study examined a cohort of approximately 500 offspring (oversampled for heavier drinkers and stratified for smoking from a population of 1529 women in prenatal care at the 5th gestational month) at birth; 8 and 18 months; and 4, 7, and 14 years of age. Covariates were examined by means of multiple regression. Birth size measures were also examined as predictors of 7-year neurodevelopmental outcomes.
Effects of alcohol were observed on weight, length, and head circumference at birth; these effects were not altered by adjustment for covariates including smoking. However, the birthweight effect is clearly transient: although alcohol effects remained observable at 8 months, they were not measurable thereafter through age 14 years.
In this population-based sample, neither birthweight nor any later size measure was as useful an indicator of the enduring effects of prenatal alcohol exposure as were certain neurodevelopmental outcomes.
本研究旨在探讨产前酒精暴露对后代从出生到14岁的体重、身高和头围的影响。
这项纵向前瞻性研究对一组约500名后代（对饮酒较多者进行了过度抽样，并根据吸烟情况对妊娠第5个月接受产前护理的1529名女性群体进行了分层）进行了研究，研究时间点包括出生时、8个月和18个月时，以及4岁、7岁和14岁时。通过多元回归分析协变量。出生时的尺寸测量也作为7岁神经发育结果的预测指标进行了研究。
观察到酒精对出生时的体重、身长和头围有影响；对包括吸烟在内的协变量进行调整后，这些影响并未改变。然而，出生体重的影响显然是短暂的：尽管在8个月时仍可观察到酒精的影响，但此后直到14岁都无法测量到。
在这个基于人群的样本中，出生体重和任何后期的尺寸测量都不如某些神经发育结果那样能有效指示产前酒精暴露的持久影响。
