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用于相对生存的灵活参数模型及其在冠心病中的应用。

Flexible parametric models for relative survival, with application in coronary heart disease.

作者信息

Nelson Christopher P, Lambert Paul C, Squire Iain B, Jones David R

机构信息

Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester, U.K.

出版信息

Stat Med. 2007 Dec 30;26(30):5486-98. doi: 10.1002/sim.3064.

Abstract

Relative survival is frequently used in population-based studies as a method for estimating disease-related mortality without the need for information on cause of death. We propose an extension to relative survival of a flexible parametric model proposed by Royston and Parmar for censored survival data. The model provides smooth estimates of the relative survival and excess mortality rates by using restricted cubic splines on the log cumulative excess hazard scale. The approach has several advantages over some of the more standard relative survival models, which adopt a piecewise approach, the main being the ability to model time on a continuous scale, the survival and hazard functions are obtained analytically and it does not use split-time data.

摘要

相对生存率常用于基于人群的研究中,作为一种无需死亡原因信息即可估计疾病相关死亡率的方法。我们提出了对Royston和Parmar针对删失生存数据提出的灵活参数模型的相对生存率的扩展。该模型通过在对数累积超额风险尺度上使用受限立方样条来提供相对生存率和超额死亡率的平滑估计。与一些采用分段方法的更标准的相对生存模型相比,该方法具有几个优点,主要优点是能够在连续尺度上对时间进行建模,生存函数和风险函数可通过解析获得,并且不使用分段时间数据。

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