原发性抗磷脂综合征中的亚临床动脉粥样硬化

Subclinical atherosclerosis in primary antiphospholipid syndrome.

作者信息

Margarita Annamaria, Batuca Joana, Scenna Giovanna, Alves Jose' Delgado, Lopez Louis, Iannaccone Luigi, Matsuura Eiji, Ames Paul R J

机构信息

Angiology Unit, Cardarelli Hospital, Naples, Italy.

出版信息

Ann N Y Acad Sci. 2007 Jun;1108:475-80. doi: 10.1196/annals.1422.050.

DOI:10.1196/annals.1422.050

PMID:17894012

Abstract

To test the atherosclerosis hypothesis in primary antiphospholipid syndrome (PAPS) we measured intima media thickness (IMT) of carotid arteries and other cardiovascular risk factors in 44 patients with PAPS (mean age 35 +/- 12 years), in 25 patients with inherited thrombophilia (mean age 40 +/- 10 years), and in 34 normal controls (mean age 38 +/- 11 years). The frequency of smoking, hypertension, and dyslipidemia was similar across groups. IMT was almost similar across groups at age groups below 40 years but IMT was greater in PAPS than controls at the common carotid (P = 0.01), at the bifurcation (P = 0.003), and at the internal carotid (P = 0.005) in the age group over 40 years. Atherosclerosis is a possibility in PAPS patients in their fourth decade of life or older.

摘要

为了验证原发性抗磷脂综合征（PAPS）中的动脉粥样硬化假说，我们测量了44例PAPS患者（平均年龄35±12岁）、25例遗传性血栓形成倾向患者（平均年龄40±10岁）和34例正常对照者（平均年龄38±11岁）的颈动脉内膜中层厚度（IMT）及其他心血管危险因素。各组间吸烟、高血压和血脂异常的发生率相似。40岁以下年龄组中，各组的IMT几乎相似，但在40岁以上年龄组中，PAPS患者在颈总动脉（P = 0.01）、分叉处（P = 0.003）和颈内动脉（P = 0.005）的IMT大于对照组。PAPS患者在40岁及以上时有可能发生动脉粥样硬化。