脑源性神经营养因子Val66Met变体与精神分裂症的发病年龄
BDNF Val66Met variant and age of onset in schizophrenia.
作者信息
Chao Helen M, Kao Hung-Teh, Porton Barbara
机构信息
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
出版信息
Am J Med Genet B Neuropsychiatr Genet. 2008 Jun 5;147B(4):505-6. doi: 10.1002/ajmg.b.30619.
Abstract
Brain-derived neurotrophic factor (BDNF) has been advanced as a candidate gene for schizophrenia by virtue of its effects on neurotransmitter systems that are dysregulated in psychiatric disorder and its involvement in the response to antipsychotic drugs. The extensively examined BDNF gene Val66Met (or rs6265) variant has been associated with schizophrenia, and studies have linked this polymorphism to brain morphology, cognitive function, and psychiatric symptoms in schizophrenia. Moreover the BDNF Val66Met variant has been reported to be associated with age of onset in schizophrenia. Genotyping of African-American subjects with schizophrenia for five BDNF coding region single nucleotide polymorphisms revealed variance only at the Val66Met allele. The results of statistical analyses indicate a relationship between the BDNF Val66Met genotype and the ages of first psychiatric hospitalization and first schizophrenia symptoms.
摘要
脑源性神经营养因子（BDNF）因其对在精神疾病中失调的神经递质系统的作用以及其在对抗精神病药物反应中的参与，已被提出作为精神分裂症的候选基因。被广泛研究的BDNF基因Val66Met（或rs6265）变体与精神分裂症有关，并且研究已将这种多态性与精神分裂症的脑形态、认知功能和精神症状联系起来。此外，BDNF Val66Met变体据报道与精神分裂症的发病年龄有关。对患有精神分裂症的非裔美国受试者的五个BDNF编码区单核苷酸多态性进行基因分型，结果显示仅在Val66Met等位基因处存在变异。统计分析结果表明BDNF Val66Met基因型与首次精神科住院年龄和首次出现精神分裂症症状的年龄之间存在关联。
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