脑源性神经营养因子（BDNF）Val66Met 多态性的电生理学相关性。
Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism.
机构信息
NICM Health Research Institute and Translational Health Research Institute (THRI), Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia.
Brain & Behaviour Research Institute and School of Psychology, University of Wollongong, Wollongong, NSW, 2522, Australia.
出版信息
Sci Rep. 2020 Oct 21;10(1):17915. doi: 10.1038/s41598-020-74780-9.
The brain-derived neurotrophic factor (BDNF) protein is essential for neuronal development. Val66Met (rs6265) is a functional polymorphism at codon 66 of the BDNF gene that affects neuroplasticity and has been associated with cognition, brain structure and function. The aim of this study was to clarify the relationship between BDNF Val66Met polymorphism and neuronal oscillatory activity, using the electroencephalogram (EEG), in a normative cohort. Neurotypical (N = 92) young adults were genotyped for the BDNF Val66Met polymorphism and had eyes open resting-state EEG recorded for four minutes. Focal increases in right fronto-parietal delta, and decreases in alpha-1 and right hemispheric alpha-2 amplitudes were observed for the Met/Met genotype group compared to Val/Val and Val/Met groups. Stronger frontal topographies were demonstrated for beta-1 and beta-2 in the Val/Met group versus the Val/Val group. Findings highlight BDNF Val66Met genotypic differences in EEG spectral amplitudes, with increased cortical excitability implications for Met allele carriers.
脑源性神经营养因子（BDNF）蛋白对于神经元发育至关重要。Val66Met（rs6265）是 BDNF 基因密码子 66 位的一种功能性多态性，影响神经可塑性，并与认知、大脑结构和功能有关。本研究旨在通过脑电图（EEG），在正常人群中阐明 BDNF Val66Met 多态性与神经元振荡活动之间的关系。92 名神经典型（N）的年轻成年人进行了 BDNF Val66Met 多态性的基因分型，并记录了四分钟睁眼静息状态 EEG。与 Val/Val 和 Val/Met 组相比，Met/Met 基因型组的右额顶 delta 频率增加，alpha-1 和右半球 alpha-2 振幅降低。与 Val/Val 组相比，Val/Met 组的 beta-1 和 beta-2 表现出更强的额叶拓扑结构。研究结果突出了 BDNF Val66Met 基因型在 EEG 频谱幅度上的差异，提示 Met 等位基因携带者皮质兴奋性增加。
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