Dzizinskiĭ A A, Puzyrev V P
Kardiologiia. 1976 Jan;16(1):114-9.
Results are presented on the study of lipid metabolism in normal individuals of different are groups with reference to the hereditary taintness as to ischaelic heart disease, and the results of correlation analysis of the level of some lipid indices of the blood of patients with ischaemic heart disease and of their relatives. In young normal individuals, whose family history is hereditary teinted with ischaemic heart disease, the level of total lipids, cholesterol, cholesterol of beta-lipoproteids, beta-lipoproteids and non-estherified fatty acids was statistically significantly higher than in the control group. In the older age groups, however, this difference becomes insignificant. The blood level of cholesterol and beta-lipoproteids is determined by genetic factors to a higher degree than the level of total lipids. The introduction of a correction factor into the correlation analysis of the above biochemical parameters indicates the changes developing with age in the proportional role of the environmental and genetic factors in the lipid metabolism disorders, the importance of the environmental factors progressively growing.
本文展示了针对不同年龄组正常个体的脂质代谢研究结果，这些个体与缺血性心脏病存在遗传易感性关联，同时还呈现了缺血性心脏病患者及其亲属血液中某些脂质指标水平的相关性分析结果。在有缺血性心脏病遗传倾向的年轻正常个体中，总脂质、胆固醇、β - 脂蛋白胆固醇、β - 脂蛋白和非酯化脂肪酸的水平在统计学上显著高于对照组。然而，在老年组中，这种差异变得不显著。胆固醇和β - 脂蛋白的血液水平比总脂质水平在更大程度上由遗传因素决定。在对上述生化参数进行相关性分析时引入校正因子，表明随着年龄增长，环境和遗传因素在脂质代谢紊乱中的比例作用发生变化，环境因素的重要性逐渐增加。
