Koshechkin V A, Titov V N, Deev A D
Kardiologiia. 1976 Feb;16(2):60-4.
The method of calculating the threshold levels of blood plasma cholesterol and triglycerids was analysed. The threshold levels were used for a genetic analysis of the relatives of the probands with coronary heart disease combined with hyperlipoproteinemia. Among 25 relatives of probands suffering coronary heart disease combined with hyperlipoproteinemia the latter was found in 15, while among 25 relatives of probands suffering coronary heart disease and having normal lipid levels hyperlipoproteinemia was found only in 2. The presented data characterise the peculiarities of the diagnosis of familial (primary) hyperlipoproteinemia and support the importance of the hereditary factor in the regulation of lipid metabolsm in the families of coronary atherosclerosis patients.
分析了计算血浆胆固醇和甘油三酯阈值水平的方法。这些阈值水平用于对患有冠心病合并高脂蛋白血症的先证者亲属进行基因分析。在25名患有冠心病合并高脂蛋白血症的先证者亲属中,有15人发现患有高脂蛋白血症,而在25名患有冠心病且血脂水平正常的先证者亲属中,仅2人发现患有高脂蛋白血症。所呈现的数据表征了家族性(原发性)高脂蛋白血症的诊断特点,并支持遗传因素在冠状动脉粥样硬化患者家族中脂质代谢调节中的重要性。