Mannami T, Baba S, Konishi M, Terao A, Kitamura A, Iida M, Shimamoto T
Department of Preventive Cardiology, National Cardiovascular, Center, Suita, Osaka, Japan.
J Stroke Cerebrovasc Dis. 2000 May-Jun;9(3):106-12. doi: 10.1053/jscd.2000.5864.
We have recently shown that extracranial carotid atherosclerosis is not uncommon in urban regions of Japan. Rural data have, however, been scarcely reported. The aim of this study was to investigate the prevalence of asymptomatic extracranial carotid lesions in rural populations compared with urban populations.
The subjects in the rural region consisted of 249 men, aged 50 to 69 years. Urban subjects were 610 men of the same age range. Carotid ultrasound examinations were performed with 7.5-MHz high-resolution ultrasonography.
Detection of severe atherosclerosis (stenosis of 50%) was significantly higher (P<.05) in rural subjects (9.6%) than in urban subjects (4.6%). Multiple regression analysis of carotid atherosclerosis showed significant relationships with age, fasting blood glucose, hypertension, pack-years of smoking, total serum cholesterol, and high-density lipoprotein cholesterol for the rural subjects as well as for the urban subjects (P<.05).
The present cross-sectional study showed that, in middle-aged men, the prevalence of severe carotid atherosclerosis was higher in rural populations compared with urban populations of Japan. This was attributed to long-term exposure to hypertension.
我们最近发现，在日本城市地区，颅外颈动脉粥样硬化并不罕见。然而，农村地区的数据报道较少。本研究的目的是调查农村人群与城市人群相比无症状颅外颈动脉病变的患病率。
农村地区的研究对象为249名年龄在50至69岁之间的男性。城市研究对象为610名年龄范围相同的男性。使用7.5兆赫高分辨率超声进行颈动脉超声检查。
农村受试者（9.6%）中重度动脉粥样硬化（狭窄50%）的检出率显著高于城市受试者（4.6%）（P<0.05）。对农村和城市受试者的颈动脉粥样硬化进行多元回归分析，结果显示其与年龄、空腹血糖、高血压、吸烟包年数、总血清胆固醇和高密度脂蛋白胆固醇均存在显著相关性（P<0.05）。
本横断面研究表明，在日本，中年男性中，农村人群重度颈动脉粥样硬化的患病率高于城市人群。这归因于长期暴露于高血压环境。
