Turpin K V L, Carroll L J, Cassidy J D, Hader W J
Northern Alberta Multiple Sclerosis Patient Care and Research Clinic, Division of Neurology, Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Mult Scler. 2007 Sep;13(8):1038-45. doi: 10.1177/1352458507078393.
Baseline data from a population-based study examining the health-related quality of life (HRQL) of MS patients about to begin disease modifying therapy was used to determine the factors associated with the HRQL of Saskatchewan adults with relapsing-remitting MS. Participants completed a self-report questionnaire regarding demographic and socioeconomic status, fatigue, comorbid medical conditions, disability level (EDSS), number of attacks in past 6 months, illness intrusiveness (Illness Intrusiveness Ratings Scale), depression (Beck Depression Inventory), and HRQL (SF-36 Health Status Survey). Multiple linear regression models were used to identify the factors associated with the physical and mental health summary scores of the SF-36. We found poorer physical HRQL in those who are female; older; not working; have musculoskeletal or respiratory problems; greater fatigue, higher disability scores, and more MS attacks. High illness intrusiveness; digestive system problems; genitourinary problems; and headaches were associated with poorer mental HRQL. Interestingly, we found an interaction between sex and age in mental HRQL, with worse mental health in older men but better mental health in older women. These findings may assist health care providers in identifying patients who may be at risk for decline in their HRQL, permitting appropriate and timely interventions.
一项基于人群的研究获取了即将开始疾病修正治疗的多发性硬化症（MS）患者的基线数据，以确定与萨斯喀彻温省复发缓解型MS成年患者健康相关生活质量（HRQL）相关的因素。参与者完成了一份关于人口统计学和社会经济状况、疲劳、合并症、残疾水平（扩展残疾状态量表，EDSS）、过去6个月内发作次数、疾病侵扰性（疾病侵扰性评定量表）、抑郁（贝克抑郁量表）以及HRQL（SF-36健康状况调查）的自我报告问卷。使用多元线性回归模型来确定与SF-36身体和心理健康总结得分相关的因素。我们发现，女性、年龄较大、未工作、有肌肉骨骼或呼吸系统问题、疲劳程度较高、残疾得分较高以及MS发作次数较多的人群，其身体HRQL较差。疾病侵扰性高、消化系统问题、泌尿生殖系统问题以及头痛与较差的心理HRQL相关。有趣的是，我们发现心理HRQL存在性别与年龄之间的交互作用，老年男性心理健康较差，而老年女性心理健康较好。这些发现可能有助于医疗保健提供者识别HRQL可能下降的风险患者，从而进行适当及时的干预。
