Okumus Gulfer, Kiyan Esen, Arseven Orhan, Tabak Levent, Diz-Kucukkaya Reyhan, Unlucerci Yesim, Abaci Neslihan, Unaltuna Nihan Erginel, Issever Halim
Department of Pulmonary Diseases, Istanbul Medical Faculty, Istanbul University, Capa-Istanbul, Turkey.
Clin Appl Thromb Hemost. 2008 Apr;14(2):168-73. doi: 10.1177/1076029607305620. Epub 2007 Sep 25.
The aim of this study was to investigate the hereditary thrombophilic risk factors in patients with venous thromboembolism (VTE) and whether these risk factors play a different role in patients with isolated pulmonary embolism (PE) as compared with patients with deep vein thrombosis (DVT) and patients with PE + DVT. The protein C (PC), protein S, antithrombin activities, homocysteine levels, and factor V Leiden (FVL) G1691A and prothrombin G20210A mutations were evaluated in 191 patients with VTE and 191 controls. The prevalence of FVL and PC deficiency were higher in patients (P = .003 and P = .02, respectively). There was no significant difference for the other risk factors. The combination of thrombophilic risk factors was significantly higher in patients with DVT + PE as compared with patients with isolated PE or DVT (P = .04). In conclusion, the most important hereditary risk factors for VTE in this study were the FVL mutation and PC deficiency.
本研究旨在调查静脉血栓栓塞症（VTE）患者的遗传性血栓形成风险因素，以及与单纯深静脉血栓形成（DVT）患者和肺栓塞合并深静脉血栓形成（PE + DVT）患者相比，这些风险因素在单纯肺栓塞（PE）患者中是否发挥不同作用。对191例VTE患者和191例对照者评估了蛋白C（PC）、蛋白S、抗凝血酶活性、同型半胱氨酸水平以及因子V莱顿（FVL）G1691A和凝血酶原G20210A突变情况。患者中FVL和PC缺乏的患病率较高（分别为P = 0.003和P = 0.02）。其他风险因素无显著差异。与单纯PE或DVT患者相比，DVT + PE患者的血栓形成风险因素组合显著更高（P = 0.04）。总之，本研究中VTE最重要的遗传性风险因素是FVL突变和PC缺乏。
