Mao Xiaole, Waldeisen John Robert, Juluri Bala Krishna, Huang Tony Jun
Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.
Lab Chip. 2007 Oct;7(10):1303-8. doi: 10.1039/b708863a. Epub 2007 Aug 2.
In this work, we report the design, fabrication, and characterization of a tunable optofluidic microlens that focuses light within a microfluidic device. The microlens is generated by the interface of two co-injected miscible fluids of different refractive indices, a 5 M CaCl(2) solution (n(D) = 1.445) and deionized (DI) water (n(D) = 1.335). When the liquids flow through a 90-degree curve in a microchannel, a centrifugal effect causes the fluidic interface to be distorted and the CaCl(2) solution bows outwards into the DI water portion. The bowed fluidic interface, coupled with the refractive index contrast between the two fluids, yields a reliable cylindrical microlens. The optical characteristics of the microlens are governed by the shape of the fluidic interface, which can be altered by simply changing the flow rate. Higher flow rates generate a microlens with larger curvature and hence shorter focal length. The changing of microlens profile is studied using both computational fluid dynamics (CFD) and confocal microscopy. The focusing effect is experimentally characterized through intensity measurements and image analysis of the focused light beam, and the experimental data are further confirmed by the results from a ray-tracing optical simulation. Our investigation reveals a simple, robust, and effective mechanism for integrating optofluidic tunable microlenses in lab-on-a-chip systems.
在这项工作中,我们报告了一种可调节的光流体微透镜的设计、制造和特性,该微透镜可在微流体装置内聚焦光线。该微透镜由两种共注入的不同折射率的互溶流体的界面产生,即5M氯化钙(CaCl₂)溶液(n(D)=1.445)和去离子(DI)水(n(D)=1.335)。当液体在微通道中流经90度弯道时,离心效应会使流体界面变形,氯化钙溶液向外弯曲进入去离子水部分。弯曲的流体界面,再加上两种流体之间的折射率差异,产生了一个可靠的圆柱形微透镜。微透镜的光学特性由流体界面的形状决定,而流体界面的形状可以通过简单地改变流速来改变。较高的流速会产生曲率更大、焦距更短的微透镜。使用计算流体动力学(CFD)和共聚焦显微镜研究了微透镜轮廓的变化。通过对聚焦光束的强度测量和图像分析对聚焦效果进行了实验表征,并且实验数据通过光线追踪光学模拟的结果得到了进一步证实。我们的研究揭示了一种在芯片实验室系统中集成光流体可调微透镜的简单、稳健且有效的机制。