Kassem Moustapha, Abdallah Basem M
Department of Endocrinology and Metabolism, University Hospital of Odense, 5000, Odense C, Denmark.
Cell Tissue Res. 2008 Jan;331(1):157-63. doi: 10.1007/s00441-007-0509-0. Epub 2007 Sep 25.
Mesenchymal stem cells (MSC) are a group of cells present in bone-marrow stroma and the stroma of various organs with the capacity for mesoderm-like cell differentiation into, for example, osteoblasts, adipocytes, and chondrocytes. MSC are being introduced in the clinic for the treatment of a variety of clinical conditions. The aim of this review is to provide an update regarding the biology of MSC, their identification and culture, and mechanisms controlling their proliferation and differentiation. We also review the current status of their clinical use. Areas in which research is needed to enhance the clinical use of MSC are emphasized.
间充质干细胞（MSC）是存在于骨髓基质和各种器官基质中的一组细胞，具有向中胚层样细胞分化的能力，例如分化为成骨细胞、脂肪细胞和软骨细胞。MSC正被引入临床用于治疗多种临床病症。本综述的目的是提供关于MSC生物学、其鉴定与培养以及控制其增殖和分化机制的最新信息。我们还综述了其临床应用的现状。强调了为加强MSC临床应用而需要开展研究的领域。
