Satir Peter, Guerra Charles, Bell Aaron J
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Cell Motil Cytoskeleton. 2007 Dec;64(12):906-13. doi: 10.1002/cm.20238.
The origin of cilia, a fundamental eukaryotic organelle, not present in prokaryotes, poses many problems, including the origins of motility and sensory function, the origins of nine-fold symmetry, of basal bodies, and of transport and selective mechanisms involved in ciliogenesis. We propose the basis of ciliary origin to be a self-assembly RNA enveloped virus that contains unique tubulin and tektin precursors. The virus becomes the centriole and basal body, which would account for the self-assembly and self-replicative properties of these organelles, in contrast to previous proposals of spirochaete origin or endogenous differentiation, which do not readily account for the centriole or its properties. The viral envelope evolves into a sensory bud. The host cell supplies the transport machinery and molecular motors to construct the axoneme. Polymerization of cytoplasmic microtubules in the 9+0 axoneme completes the 9+2 pattern.
纤毛是原核生物所没有的一种基本真核细胞器，其起源引发了许多问题，包括运动性和感觉功能的起源、九重对称性的起源、基体的起源以及纤毛发生过程中涉及的运输和选择机制的起源。我们提出纤毛起源的基础是一种自我组装的RNA包膜病毒，它含有独特的微管蛋白和轴纤丝蛋白前体。这种病毒成为中心粒和基体，这可以解释这些细胞器的自我组装和自我复制特性，这与之前关于螺旋体起源或内源性分化的提议形成对比，那些提议难以解释中心粒或其特性。病毒包膜演变成一个感觉芽。宿主细胞提供运输机制和分子马达来构建轴丝。9+0轴丝中细胞质微管的聚合完成了9+2模式。
