延髓和颈髓的质子磁共振波谱成像
Proton MR spectroscopic imaging of the medulla and cervical spinal cord.
作者信息
Edden Richard A E, Bonekamp David, Smith Mari A, Dubey Prachi, Barker Peter B
机构信息
Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
J Magn Reson Imaging. 2007 Oct;26(4):1101-5. doi: 10.1002/jmri.21008.
PURPOSE
To demonstrate the feasibility of quantitative, one-dimensional proton MR spectroscopic imaging (1D-MRSI) of the upper cervical spine and medulla at 3.0 Tesla.
MATERIALS AND METHODS
A method was developed for 1D-point-resolved spectroscopy sequence (PRESS)-MRSI, exciting signal in five voxels extending from the pontomedullary junction to the level of the C3 vertebra, and performed in 10 healthy volunteers to generate control data.
RESULTS
High-resolution 1D-MRSI data were obtained from all 10 subjects. Upper cervical spine concentrations of choline, creatine, and N-acetyl aspartate were estimated to be 2.8 +/- 0.5, 8.8 +/- 1.8, and 10.9 +/- 2.7 mM, respectively, while in the medulla they were 2.6 +/- 0.5, 9.1 +/- 1.7, and 10.8 +/- 0.9 mM.
CONCLUSION
Quantitative 1D-MRSI of the upper cervical spine has been shown to be feasible at 3.0 Tesla.
目的
证明在3.0特斯拉磁场强度下对上颈椎和延髓进行定量一维质子磁共振波谱成像（1D-MRSI）的可行性。
材料与方法
开发了一种用于一维点分辨波谱序列（PRESS）-MRSI的方法，在从脑桥延髓交界处延伸至C3椎体水平的五个体素中激发信号，并在10名健康志愿者中进行，以生成对照数据。
结果
所有10名受试者均获得了高分辨率的1D-MRSI数据。上颈椎中胆碱、肌酸和N-乙酰天门冬氨酸的浓度估计分别为2.8±0.5、8.8±1.8和10.9±2.7 mM，而在延髓中它们分别为2.6±0.5、9.1±1.7和10.8±0.9 mM。
结论
已证明在3.0特斯拉磁场强度下对上颈椎进行定量1D-MRSI是可行的。
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