Salameh Najat, Peeters Frank, Sinkus Ralph, Abarca-Quinones Jorge, Annet Laurence, Ter Beek Leon C, Leclercq Isabelle, Van Beers Bernard E
Diagnostic Radiology Unit, Université Catholique de Louvain, Brussels, Belgium.
J Magn Reson Imaging. 2007 Oct;26(4):956-62. doi: 10.1002/jmri.21099.
To determine the correlations between the viscoelastic parameters of the liver measured with in vivo MR elastography and quantitative analysis of liver fibrosis.
MR elastography of the liver was performed in 10 rats with hepatic fibrosis induced by intraperitoneal carbon tetrachloride (CCl(4)) injections and five normal rats. Longitudinal waves of 200 MHz were transmitted into the liver with a mechanical transducer. Wave propagation into the liver was analyzed with a phase-locked spin-echo sequence at 1.5 T. The viscoelastic parameters, obtained with the Voigt model, were correlated with automatic image analysis of the fibrotic areas and with analysis of the hydroxyproline content of the liver.
Substantial correlations were observed between the shear viscoelastic parameters and the percentage of fibrosis at automatic image analysis (r = 0.7, P = 0.005 for the elasticity, and r = 0.8, P = 0.001 for the viscosity) and moderate correlations were seen between the shear viscoelastic parameters and the hydroxyproline content (r = 0.6, P = 0.016 for the elasticity and r = 0.5, P = 0.041 for the viscosity).
The viscoelastic parameters of the liver measured with in vivo MR elastography correlate with quantitative analysis of liver fibrosis. These results suggest that MR elastography is a promising noninvasive method to quantify liver fibrosis.
确定通过体内磁共振弹性成像测量的肝脏粘弹性参数与肝纤维化定量分析之间的相关性。
对10只经腹腔注射四氯化碳（CCl₄）诱导肝纤维化的大鼠和5只正常大鼠进行肝脏磁共振弹性成像检查。使用机械换能器将200MHz的纵波传入肝脏。在1.5T下用锁相自旋回波序列分析波在肝脏中的传播。用Voigt模型获得的粘弹性参数与纤维化区域的自动图像分析以及肝脏羟脯氨酸含量的分析相关联。
在自动图像分析中，剪切粘弹性参数与纤维化百分比之间存在显著相关性（弹性方面，r = 0.7，P = 0.005；粘性方面，r = 0.8，P = 0.001），并且剪切粘弹性参数与羟脯氨酸含量之间存在中等相关性（弹性方面，r = 0.6，P = 0.016；粘性方面，r = 0.5，P = 0.041）。
通过体内磁共振弹性成像测量的肝脏粘弹性参数与肝纤维化定量分析相关。这些结果表明磁共振弹性成像是一种有前景的非侵入性肝纤维化定量方法。
