Huwart Laurent, Peeters Frank, Sinkus Ralph, Annet Laurence, Salameh Najat, ter Beek Leon C, Horsmans Yves, Van Beers Bernard E
Diagnostic Radiology Unit, Université Catholique de Louvain, Brussels, Belgium.
NMR Biomed. 2006 Apr;19(2):173-9. doi: 10.1002/nbm.1030.
The aim of this study was to assess the feasibility of using non-invasive MR elastography for determining the stage of liver fibrosis. Twenty-five consecutive patients who had liver biopsy for suspicion of chronic liver disease were included in the study. The stage of fibrosis on the biopsies was assessed according to the METAVIR scoring system from F0, no fibrosis, to F4, cirrhosis. MR elastography was performed by transmitting low-frequency (65 Hz) mechanical waves into the liver with a transducer placed at the back of the patients. The MR pulse sequence was a motion-sensitized spin-echo sequence, phase-locked to the mechanical excitation. The phase maps were processed to obtain shear elasticity and shear viscosity maps. The mean hepatic shear elasticity increased with increasing stage of fibrosis. The mean elasticity was 2.24 +/- 0.23 kPa in the 11 patients without substantial fibrosis (F0-F1 grades), 2.56 +/- 0.24 kPa in the four patients with substantial fibrosis (F2-F3) and 4.68 +/- 1.61 kPa in the 10 patients with cirrhosis (F4). The differences between groups were statistically significant (p <or= 0.05). The mean shear viscosity was significantly higher in the patients with cirrhosis (5.19 +/- 1.85 Pa x s) than in the patients without cirrhosis (2.39 +/- 0.86 Pa x s in F0-F1 and 2.27 +/- 0.38 Pa x s in F2-F3 patients). It is concluded that non-invasive MR elastography is a feasible method to assess the stage of liver fibrosis.
本研究的目的是评估使用非侵入性磁共振弹性成像来确定肝纤维化分期的可行性。连续25例因怀疑患有慢性肝病而接受肝活检的患者被纳入本研究。根据METAVIR评分系统评估活检组织的纤维化分期，从F0（无纤维化）到F4（肝硬化）。通过将低频（65Hz）机械波通过置于患者背部的换能器传入肝脏来进行磁共振弹性成像。磁共振脉冲序列是一种与机械激发锁相的运动敏感自旋回波序列。对相位图进行处理以获得剪切弹性和剪切粘度图。平均肝剪切弹性随纤维化分期增加而升高。11例无明显纤维化（F0 - F1级）患者的平均弹性为2.24±0.23kPa，4例有明显纤维化（F2 - F3）患者的平均弹性为2.56±0.24kPa，10例肝硬化（F4）患者的平均弹性为4.68±1.61kPa。组间差异具有统计学意义（p≤0.05）。肝硬化患者的平均剪切粘度（5.19±1.85Pa·s）显著高于无肝硬化患者（F0 - F1患者为2.39±0.86Pa·s，F2 - F3患者为2.27±0.38Pa·s）。结论是非侵入性磁共振弹性成像是评估肝纤维化分期的一种可行方法。
