Reeves Roy R, Hammer Jeffrey S, Pendarvis Richard O
Mental Health Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, Mississippi 39216, USA.
Pharmacotherapy. 2007 Oct;27(10):1462-6. doi: 10.1592/phco.27.10.1462.
Carisoprodol is a commonly used centrally acting muscle relaxant. A number of case reports have suggested that the drug may have abuse potential, presumably because it is metabolized to the anxiolytic drug, meprobamate, which is a controlled substance at the federal level. Two recent case reports described symptoms of withdrawal after the cessation of carisoprodol. We present two additional cases that support the concept of a withdrawal syndrome with this drug. Symptoms of carisoprodol withdrawal include anxiety, tremulousness, insomnia, jitteriness, muscle twitching, and hallucinations. These symptoms are most likely caused by withdrawal from the meprobamate that accumulates after large amounts of carisoprodol are ingested. Although carisoprodol is not a controlled substance at the federal level, clinicians should be aware of its significant potential for abuse.
卡立普多是一种常用的中枢性肌肉松弛剂。一些病例报告表明，该药物可能具有滥用潜力，据推测是因为它会代谢为抗焦虑药物甲丙氨酯，而甲丙氨酯在联邦层面属于管制物质。最近有两份病例报告描述了停用卡立普多后的戒断症状。我们在此呈现另外两例病例，以支持该药物存在戒断综合征这一概念。卡立普多戒断症状包括焦虑、震颤、失眠、神经过敏、肌肉抽搐和幻觉。这些症状很可能是由于大量摄入卡立普多后积累的甲丙氨酯戒断所致。尽管卡立普多在联邦层面并非管制物质，但临床医生应意识到其存在显著的滥用潜力。
