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来自巴西矛头蝮蛇毒液的Lys49-磷脂酶A2同系物与对溴苯甲酰溴和α-生育酚抑制剂复合的初步X射线晶体学研究。

Preliminary X-ray crystallographic studies of a Lys49-phospholipase A2 homologue from Bothrops pirajai venom complexed with p-bromo-phenacyl bromide and alpha-tocopherol inhibitors.

作者信息

Dos Santos Juliana I, Marchi-Salvador Daniela P, Fernandes Carlos A H, Silveira Lucas B, Soares Andreimar M, Fontes Marcos R M

机构信息

Departamento de Física e Biofísica, Instituto de Biociências, UNESP, C. P. 510, CEP 18618-000, Botucatu-SP, Brazil.

出版信息

Protein Pept Lett. 2007;14(7):698-701. doi: 10.2174/092986607781483796.

DOI:10.2174/092986607781483796
PMID:17897096
Abstract

PrTX-I, a non-catalytic and myotoxic Lys49-PLA(2) from Bothrops pirajai venom has been crystallized alone and in complex with bromophenacyl bromide (BPB), alpha tocopherol and alpha tocopherol acetate inhibitors. These crystals have shown to diffract X-rays between 2.34 and 1.65 A resolution. All complexes crystals are isomorphous and belong to the space group P2(1) whereas native PrTX-I crystals belong to the P3(1)21.

摘要

PrTX-I是一种来自皮拉杰矛头蝮蛇毒的非催化性且具有肌毒性的Lys49 - PLA(2)，它已单独结晶，并与溴苯甲酰溴（BPB）、α-生育酚和α-生育酚醋酸酯抑制剂形成复合物结晶。这些晶体在2.34至1.65埃分辨率之间能产生X射线衍射。所有复合物晶体都是同晶型的，属于空间群P2(1)，而天然PrTX-I晶体属于P3(1)21。

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