Ogier J-C, Casalta E, Farrokh C, Saïhi A
Unité des Bactéries Lactiques et Pathogènes Opportunistes, INRA, Domaine de Vilvert, 78350 Jouy-en-Josas, France.
Int J Food Microbiol. 2008 Sep 1;126(3):286-90. doi: 10.1016/j.ijfoodmicro.2007.08.012. Epub 2007 Aug 22.
Although Leuconostoc genus is "generally recognized as safe" (GRAS), a few clinically human infections cases by this microorganism have been reported in the literature, leading to their classification as opportunistic pathogens. However, these reported cases concern only severe immunodepressed patients, and none direct relations have yet been proven between Leuconostoc isolation and human diseases. Moreover, no cases of infections have been directly linked to the consumption of fermented food. Considering the long history of use of Leuconostoc in dairy industry, and their poor incidence in human infections cases, this bacterial genus may be reasonably considered as " safe " for its use in fermented dairy products.
尽管明串珠菌属被“普遍认为是安全的”（GRAS），但文献中已报道了该微生物引起的几例临床人类感染病例，导致它们被归类为机会致病菌。然而，这些报道的病例仅涉及严重免疫抑制患者，且尚未证实明串珠菌的分离与人类疾病之间存在直接关系。此外，没有感染病例与食用发酵食品直接相关。考虑到明串珠菌在乳制品行业的长期使用历史，以及它们在人类感染病例中的低发生率，该细菌属在发酵乳制品中的使用可被合理认为是“安全的”。
