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从马皮肤分离出的……菌对……的抗生物膜活性

Antibiofilm Activity of spp. and Isolated from Equine Skin against .

作者信息

Styková Eva, Nemcová Radomíra, Maďar Marián, Bujňáková Dobroslava, Mucha Rastislav, Gancarčíková Soňa, Requena Domenech Francisco

机构信息

Clinic of Horses, University Veterinary Hospital, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia.

Department of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia.

出版信息

Life (Basel). 2022 Dec 17;12(12):2135. doi: 10.3390/life12122135.

DOI:10.3390/life12122135
PMID:36556500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9787530/
Abstract

The aim of this study was to evaluate the antimicrobial and antibiofilm activity of , and , isolated from equine skin, against biofilm-forming CCM 4223 and clinical isolate methicillin-resistant (MRSA). Non-neutralized cell-free supernatants (nnCFS) of tested skin isolates completely inhibited the growth and biofilm formation of strains and caused dispersion of the 24 h preformed biofilm in the range of 21-90%. The majority of the pH-neutralized cell-free supernatants (nCFS) of skin isolates inhibited the biofilm formation of both strains in the range of 20-100%. The dispersion activity of nCFS ranged from 17 to 77% and was significantly lower than that of nnCFS, except for 3T27 against CCM 4223. Changes in the growth of CCM 4223 in the presence of catalase- or trypsin-treated 4/2D23 and 4/8D37 nCFS indicated the role of peroxides and/or bacteriocin in their antimicrobial activities. For the first time, the presence of the gene, associated with biosurfactants production, was detected in . The results of this study showed that selected isolates may have the potential for the prevention and treatment of biofilm-forming infections.

摘要

本研究的目的是评估从马皮肤分离出的[具体物质未明确]对形成生物膜的马源嗜皮菌CCM 4223和临床分离的耐甲氧西林金黄色葡萄球菌（MRSA）的抗菌和抗生物膜活性。受试皮肤分离株的未中和无细胞上清液（nnCFS）完全抑制了[具体菌株未明确]菌株的生长和生物膜形成，并使24小时预先形成的生物膜分散，分散率在21%-90%之间。大多数皮肤分离株的pH中和无细胞上清液（nCFS）在20%-100%的范围内抑制了两种[具体菌株未明确]菌株的生物膜形成。nCFS的分散活性在17%-77%之间，除了3T27对CCM 4223的情况外，显著低于nnCFS。在过氧化氢酶或胰蛋白酶处理的4/2D23和4/8D37 nCFS存在下，CCM 4223生长的变化表明过氧化物和/或细菌素在其抗菌活性中的作用。首次在[具体菌株未明确]中检测到与生物表面活性剂产生相关的[具体基因未明确]基因。本研究结果表明，所选分离株可能具有预防和治疗形成生物膜的[具体感染菌未明确]感染的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/836773035009/life-12-02135-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/7a8ef058f042/life-12-02135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/10e307ca0326/life-12-02135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/e0677e2497e6/life-12-02135-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/4b9f2559560b/life-12-02135-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/4346f55f7d10/life-12-02135-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/9d2ab550a9c6/life-12-02135-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/c937d22b1ee1/life-12-02135-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/6cfd88d43e65/life-12-02135-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/836773035009/life-12-02135-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/7a8ef058f042/life-12-02135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/10e307ca0326/life-12-02135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/e0677e2497e6/life-12-02135-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/4b9f2559560b/life-12-02135-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/4346f55f7d10/life-12-02135-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/9d2ab550a9c6/life-12-02135-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/c937d22b1ee1/life-12-02135-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/6cfd88d43e65/life-12-02135-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5283/9787530/836773035009/life-12-02135-g009.jpg

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