Mao Chun-Hui, Wang Kai-Liang, Wang Zi-Wen, Ou Xiao-Ming, Huang Run-Qiu, Bi Fu-Chun, Wang Qing-Min
State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
Bioorg Med Chem. 2008 Jan 1;16(1):488-94. doi: 10.1016/j.bmc.2007.09.018. Epub 2007 Sep 14.
A series of novel N'-tert-butyl- N'-substitutedbenzoyl-N-5-chloro-6-chromanecarbohydrazide derivatives were synthesized, and their larvicidal activities against Oriental armyworm were evaluated. The results of bioassays indicated that most of these title compounds exhibit higher larvicidal activities than RH-5849, and several of them somewhat lower than the commercial insecticide tebufenozide. The larvicidal activities are strongly associated with the types and patterns of substitution on the benzene, and 3,5-dimethyl, 2-nitro-4-chloro and 3-methyl derivatives are most prominent in increasing activity. Toxicity assays indicated that these derivatives could induce a premature, abnormal, and lethal larval moult.
合成了一系列新型的N'-叔丁基-N'-取代苯甲酰基-N-5-氯-6-色满甲酰肼衍生物，并评估了它们对东方粘虫的杀幼虫活性。生物测定结果表明，这些目标化合物中的大多数表现出比RH-5849更高的杀幼虫活性，其中一些略低于商业杀虫剂虫酰肼。杀幼虫活性与苯环上的取代类型和模式密切相关，3,5-二甲基、2-硝基-4-氯和3-甲基衍生物在提高活性方面最为突出。毒性试验表明，这些衍生物可诱导幼虫提前、异常和致死性蜕皮。
