Sawada Yoshihiro, Yanai Toshiaki, Nakagawa Harumi, Tsukamoto Yoshihisa, Yokoi Shinji, Yanagi Mikio, Toya Tetsuya, Sugizaki Hiroyasu, Kato Yasuhito, Shirakura Hidetoshi, Watanabe Tetsuo, Yajima Yoshimi, Kodama Seiichirou, Masui Akio
Agroscience Research Laboratories, Sankyo Co Ltd, 1041, Yasu, Yasu-cho, Yasu-gun, Shiga-ken 520-2342, Japan.
Pest Manag Sci. 2003 Jan;59(1):25-35. doi: 10.1002/ps.604.
The N'-benzoyl group of N-tert-butyl-N'-benzoyl-3,5-dimethylbenzohydrazide (1) was converted to a series of benzoheterocyclecarbonyl groups in order to investigate the potential usefulness of superimposing a hydrazine insecticide on 20-hydroxyecdysone. A series of analogues with benzodioxole, benzodioxane, benzodioxapine, indole, benzoxazole, benzoxazine or benzothiazole instead of the phenyl group of (1) were synthesized and tested for their insecticidal activity against the common cutworm (Spodoptera litura F). N-tert-Butyl-N'-(3,5-dimethylbenzoyl)-1,3-benzodioxole-5-carbohydrazide and N-tert-butyl-N'-(3,5-dimethylbenzoyl)-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide showed high insecticidal activities, superior to that of (1) and equal to that of the commercial insecticide tebufenozide (RH-5992).
为了研究将肼类杀虫剂与20-羟基蜕皮激素叠加的潜在用途，N-叔丁基-N'-苯甲酰基-3,5-二甲基苯甲酰肼（1）的N'-苯甲酰基被转化为一系列苯并杂环羰基。合成了一系列用苯并二恶唑、苯并二恶烷、苯并二恶平、吲哚、苯并恶唑、苯并恶嗪或苯并噻唑取代（1）中苯基的类似物，并测试了它们对斜纹夜蛾（Spodoptera litura F）的杀虫活性。N-叔丁基-N'-（3,5-二甲基苯甲酰基）-1,3-苯并二恶唑-5-甲酰肼和N-叔丁基-N'-（3,5-二甲基苯甲酰基）-2,3-二氢-1,4-苯并二恶烷-6-甲酰肼显示出高杀虫活性，优于（1）且与市售杀虫剂虫酰肼（RH-5992）相当。
