Abankwa Daniel, Gorfe Alemayehu A, Hancock John F
Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia.
Semin Cell Dev Biol. 2007 Oct;18(5):599-607. doi: 10.1016/j.semcdb.2007.08.003. Epub 2007 Aug 19.
H-, N- and K-ras4B are lipid-anchored, peripheral membrane guanine nucleotide binding proteins. Recent work has shown that Ras proteins are laterally segregated into non-overlapping, dynamic domains of the plasma membrane called nanoclusters. This lateral segregation is important to specify Ras interactions with membrane-associated proteins, effectors and scaffolding proteins and is critical for Ras signal transduction. Here we review biological, in vitro and structural data that provide insight into the molecular basis of how palmitoylated Ras proteins are anchored to the plasma membrane. We explore possible mechanisms for how the interactions of H-ras with a lipid bilayer may drive nanocluster formation.
H-Ras、N-Ras和K-Ras4B是脂质锚定的外周膜鸟嘌呤核苷酸结合蛋白。最近的研究表明，Ras蛋白横向分隔成质膜上不重叠的动态区域，称为纳米簇。这种横向分隔对于确定Ras与膜相关蛋白、效应器和支架蛋白的相互作用很重要，并且对Ras信号转导至关重要。在这里，我们综述了生物学、体外实验和结构数据，这些数据有助于深入了解棕榈酰化Ras蛋白锚定到质膜的分子基础。我们探讨了H-Ras与脂质双层的相互作用可能驱动纳米簇形成的潜在机制。
