Connolly Gregory N, Alpert Hillel R, Wayne Geoffrey Ferris, Koh Howard
Harvard School of Public Health, Division of Public Health Practice, Landmark Building, 677 Huntington Avenue, Boston, MA 02115, USA.
Tob Control. 2007 Oct;16(5):e5. doi: 10.1136/tc.2006.019695.
To determine whether nicotine yields in the smoke of cigarettes would show an overall increase over time or an increasing trend limited to any particular market category (eg, full flavour vs light, medium (mild) or ultralight; mentholated vs non-mentholated), manufacturer, or brand family or brand style, and whether nicotine yields in smoke would be associated with measurable trends in cigarette design.
Machine-based measures of nicotine yield in smoke and measures of cigarette design features related to nicotine delivery (ventilation, nicotine content in the tobacco rod and number of puffs), as well as market category descriptors, were obtained from annual reports filed with the Massachusetts Department of Public by tobacco manufacturers for 1997-2005. Trends in nicotine yield and its relationship with design features and market parameters were analysed with multilevel mixed-effects regression modelling procedures.
A statistically significant trend was confirmed in increased nicotine yield, of 0.019 (1.1%) mg/cig/year over the period 1997-2005 and 0.029 (1.6%) mg/cig/year over the period 1998-2005. The increasing trend was observed in all major market categories (mentholated vs non-mentholated, and full flavour vs light, medium (mild) or ultralight). Nicotine yield in smoke was positively associated with nicotine concentration in the tobacco and number of puffs per cigarette, both of which showed increasing trends during the study period.
This study confirms increased machine-measured levels of nicotine, the addictive agent in cigarettes, in smoke, to be a result of increased nicotine in the tobacco rod and other design modifications.
确定香烟烟雾中的尼古丁含量是否会随时间总体上升,或上升趋势是否仅限于特定市场类别(如全味型与淡味、中味(柔和)或超淡味;薄荷型与非薄荷型)、制造商、品牌家族或品牌风格,以及烟雾中的尼古丁含量是否与香烟设计的可测量趋势相关。
从烟草制造商向马萨诸塞州公共卫生部提交的1997 - 2005年年报中获取基于机器测量的烟雾中尼古丁含量以及与尼古丁输送相关的香烟设计特征(通风性、烟丝中的尼古丁含量和吸数)的测量数据,以及市场类别描述。使用多水平混合效应回归建模程序分析尼古丁含量的趋势及其与设计特征和市场参数的关系。
证实了尼古丁含量存在统计学上的显著趋势,1997 - 2005年期间每年增加0.019(1.1%)毫克/支香烟,1998 - 2005年期间每年增加0.029(1.6%)毫克/支香烟。在所有主要市场类别(薄荷型与非薄荷型,全味型与淡味、中味(柔和)或超淡味)中均观察到了上升趋势。烟雾中的尼古丁含量与烟丝中的尼古丁浓度以及每支香烟的吸数呈正相关,在研究期间这两者均呈上升趋势。
本研究证实,机器测量的香烟烟雾中成瘾剂尼古丁含量的增加是由于烟丝中尼古丁含量增加及其他设计改进所致。