Wischmeyer Paul E, Johnson Bradley R, Wilson Joel E, Dingmann Colleen, Bachman Heidi M, Roller Evan, Tran Zung Vu, Henthorn Thomas K
Department of Anesthesiology, University of Colorado, Denver, Colorado, USA.
Anesth Analg. 2007 Oct;105(4):1066-71, table of contents. doi: 10.1213/01.ane.0000270215.86253.30.
Although propofol has not traditionally been considered a drug of abuse, subanesthetic doses may have an abuse potential. We used this survey to assess prevalence and outcome of propofol abuse in academic anesthesiology programs.
E-mail surveys were sent to the 126 academic anesthesiology training programs in the United States.
The survey response rate was 100%. One or more incidents of propofol abuse or diversion in the past 10 yr were reported by 18% of departments. The observed incidence of propofol abuse was 10 per 10,000 anesthesia providers per decade, a fivefold increase from previous surveys of propofol abuse (P = 0.005). Of the 25 reported individuals abusing propofol, 7 died as a result of the propofol abuse (28%), 6 of whom were residents. There was no established system to control or monitor propofol as is done with opioids at 71% of programs. There was an association between lack of control of propofol (e.g., pharmacy accounting) at the time of abuse and incidence of abuse at the program (P = 0.048).
Propofol abuse in academic anesthesiology likely has increased over the last 10 yr. Much of the mortality is in residents. Most programs have no pharmacy accounting or control of propofol stocks. This may be of concern, given that all programs reporting deaths from propofol abuse were centers in which there was no pharmacy accounting for the drug.
尽管丙泊酚传统上不被视为滥用药物，但亚麻醉剂量可能具有滥用潜力。我们通过这项调查评估学术麻醉学项目中丙泊酚滥用的发生率和后果。
向美国126个学术麻醉学培训项目发送电子邮件调查。
调查回复率为100%。18%的科室报告在过去10年中有1起或多起丙泊酚滥用或转移事件。观察到的丙泊酚滥用发生率为每十年每10000名麻醉提供者中有10例，比之前丙泊酚滥用调查结果增加了五倍（P = 0.005）。在报告的25名滥用丙泊酚的个体中，7人因丙泊酚滥用死亡（28%），其中6人为住院医师。71%的项目没有像对阿片类药物那样建立控制或监测丙泊酚的系统。滥用丙泊酚时缺乏控制（如药房账目管理）与项目中的滥用发生率之间存在关联（P = 0.048）。
在过去10年中，学术麻醉学领域的丙泊酚滥用情况可能有所增加。大部分死亡发生在住院医师中。大多数项目没有药房账目管理或丙泊酚库存控制。鉴于所有报告有丙泊酚滥用死亡事件的项目都是没有该药物药房账目的中心，这可能令人担忧。
