Moppett Iain K, Hardman Jonathan G
Division of Anaesthesia and Intensive Care, Queen's Medical Centre Campus, Nottingham University Hospitals, Nottingham, UK.
Anesth Analg. 2007 Oct;105(4):1094-103, table of contents. doi: 10.1213/01.ane.0000284620.37846.e5.
Various groups have constructed simulations and models of cerebral blood flow and oxygenation, each with its strengths and weaknesses. We describe the development and validation of a novel computational model, the Nottingham cerebral simulator (NCS), designed for experimental and teaching use.
Physiological hypotheses were converted into differential equations; these are solved numerically with respect to time. A battery of tests was derived from published literature against which to test the simulation: static and dynamic autoregulation responses; carbon dioxide reactivity; brain tissue oxygenation. The NCS was programmed to simulate the methodologies of published experiments and the results of the simulation and the published data were compared.
The NCS results are qualitatively and quantitatively similar to published data. The values for regulatory indices were (published values in parentheses): index of autoregulation 0.9 (0.9); transient hyperemic response ratio 1.3 (1.3), carbon dioxide reactivity 2.4%-4.7% mm Hg(-1) (2-4.5); brain tissue oxygen tension 22 mm Hg (20-100).
The NCS is a credible model of cerebral blood flow and oxygenation, which warrants further use as an experimental and teaching tool.
多个研究团队构建了脑血流和氧合的模拟模型，各有优缺点。我们描述了一种新型计算模型——诺丁汉脑模拟器（NCS）的开发与验证，该模型设计用于实验和教学。
将生理假设转化为微分方程，对其进行时间上的数值求解。从已发表的文献中得出一系列测试，用于检验模拟结果：静态和动态自动调节反应；二氧化碳反应性；脑组织氧合。对NCS进行编程以模拟已发表实验的方法，并将模拟结果与已发表数据进行比较。
NCS的结果在定性和定量上与已发表数据相似。调节指数的值为（括号内为已发表的值）：自动调节指数0.9（0.9）；短暂充血反应比1.3（1.3），二氧化碳反应性2.4% - 4.7% mmHg⁻¹（2 - 4.5）；脑组织氧张力22 mmHg（20 - 100）。
NCS是一种可靠的脑血流和氧合模型，值得进一步用作实验和教学工具。
