Barthélémy Jean-Claude, Pichot Vincent, Dauphinot Virginie, Celle Sébastien, Laurent Bernard, Garcin Arnauld, Maudoux Delphine, Kerleroux Judith, Lacour Jean-René, Kossovsky Michel, Gaspoz Jean-Michel, Roche Frédéric
Clinical and Exercise Physiology Laboratory, University Hospital, Saint-Etienne, France.
Neuroepidemiology. 2007;29(1-2):18-28. doi: 10.1159/000108914.
Transversal studies have underlined the association between the decline in autonomic nervous system (ANS) activity and all-cause mortality. However, the predictive value of ANS has never been prospectively assessed in a general population-based cohort.
The PROOF (PROgnostic indicator OF cardiovascular and cerebrovascular events) cohort study was designed to prospectively assess the predictive value of ANS activity level in the general population, with regard to cardiovascular and cerebrovascular events, and death. This predictive power will be compared with the usual and newly discovered risk factors for the purposes of developing a risk model.
A prospective cohort of elderly subjects aged 65 years upon study entry were recruited from the electoral list of the city of Saint-Etienne, France. Three initial 2-year examination programs were scheduled for 7 years (2001-2007), followed by late events monitoring. At each examination, ANS activity was assessed along with clinical and biological cardiovascular risk factors, brain MRI, neuropsychological evaluation, physical activity profile, and sleep-related breathing disorders. The main study outcomes are stroke, myocardial infarction and death from any cause. A cohort consisting of 1,011 subjects aged 65.6 (0.8) years was constituted.
Despite other selective characteristics, the associations between ANS activity and events will be applicable to other populations.
横向研究强调了自主神经系统（ANS）活动下降与全因死亡率之间的关联。然而，ANS的预测价值从未在基于普通人群的队列中进行过前瞻性评估。
PROOF（心血管和脑血管事件的预后指标）队列研究旨在前瞻性评估普通人群中ANS活动水平对心血管和脑血管事件及死亡的预测价值。为了建立一个风险模型，将把这种预测能力与常见的和新发现的风险因素进行比较。
从法国圣艾蒂安市的选民名单中招募了研究开始时年龄为65岁的老年受试者的前瞻性队列。最初安排了三个为期2年的检查项目，为期7年（2001 - 2007年），随后进行后期事件监测。每次检查时，都会评估ANS活动以及临床和生物心血管危险因素、脑部MRI、神经心理学评估、身体活动状况和睡眠相关呼吸障碍。主要研究结局为中风、心肌梗死和任何原因导致的死亡。构成了一个由1011名年龄为65.6（0.8）岁的受试者组成的队列。
尽管存在其他选择性特征，但ANS活动与事件之间的关联将适用于其他人群。
