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治疗性禁食:65 岁及以上的患者准备好了吗?

Therapeutic Fasting: Are Patients Aged 65 and Over Ready?

机构信息

Department of Internal Medicine, Saint-Etienne University Hospital, CEDEX 02, 42055 Saint-Etienne, France.

Team GIMAP, CIRI-Centre International de Recherche en Infectiologie, Université de Lyon, Université Jean Monnet, Université Claude Bernard Lyon 1, INSERM, U1111, Centre National de la Recherche Scientifique (CNRS), UMR530, CEDEX 02, 42023 Saint-Etienne, France.

出版信息

Nutrients. 2022 May 10;14(10):2001. doi: 10.3390/nu14102001.

DOI:10.3390/nu14102001
PMID:35631147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9143805/
Abstract

While being the main potential beneficiaries of therapeutic fasting's health benefits, the elderly are frequently thought of as being too fragile to fast. The main objective of our survey was to review the knowledge, practices, and acceptability of therapeutic fasting in subjects aged 65 years and over. From September 2020 to March 2021, an online questionnaire was sent to subjects aged 65 and over, using the mailing list of local organizations working in the field of aging. The mean age of the 290 respondents was 73.8 ± 6.5 years, 75.2% were women and 54.1% had higher education. Among the respondents, 51.7% had already fasted and 80.7% deemed therapeutic fasting interesting, 83.1% would be willing to fast if it was proven beneficial for their health, and 77.2% if it was proven to decrease the burden of chronic diseases. Subjects aged 65 to 74 years considered themselves as having the greatest physical and motivational abilities to perform therapeutic fasting. People aged 65 years, or more, are interested in therapeutic fasting and a large majority would be ready to fast if such practice was proven beneficial. These results pave the way for future clinical trials evaluating therapeutic fasting in elderly subjects.

摘要

尽管老年人是治疗性禁食健康益处的主要潜在受益者,但他们常常被认为太脆弱而不能禁食。我们调查的主要目的是回顾 65 岁及以上人群对治疗性禁食的知识、实践和可接受性。从 2020 年 9 月到 2021 年 3 月,我们使用从事老龄化领域工作的当地组织的邮件列表,向 65 岁及以上的人群发送了在线问卷。290 名受访者的平均年龄为 73.8 ± 6.5 岁,75.2%为女性,54.1%具有高等教育学历。在受访者中,51.7%已经禁食,80.7%认为治疗性禁食很有趣,如果证明对健康有益,83.1%愿意禁食,如果证明可以减轻慢性病的负担,77.2%愿意禁食。65 至 74 岁的受访者认为自己拥有进行治疗性禁食的最大身体和动力能力。65 岁及以上的人群对治疗性禁食感兴趣,如果这种做法被证明有益,绝大多数人都愿意禁食。这些结果为未来评估老年人群体中治疗性禁食的临床试验铺平了道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30dc/9143805/d2c69feb9a23/nutrients-14-02001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30dc/9143805/9858c0214266/nutrients-14-02001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30dc/9143805/d2c69feb9a23/nutrients-14-02001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30dc/9143805/9858c0214266/nutrients-14-02001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30dc/9143805/d2c69feb9a23/nutrients-14-02001-g002.jpg

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Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial.多中心随机 2 期 DIRECT 试验中,禁食模拟饮食作为乳腺癌新辅助化疗的辅助治疗。
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