Smith Stuart, Tsai Shiou-Chuan
Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, California 94609, USA.
Nat Prod Rep. 2007 Oct;24(5):1041-72. doi: 10.1039/b603600g. Epub 2007 Jul 2.
This review chronicles the synergistic growth of the fields of fatty acid and polyketide synthesis over the last century. In both animal fatty acid synthases and modular polyketide synthases, similar catalytic elements are covalently linked in the same order in megasynthases. Whereas in fatty acid synthases the basic elements of the design remain immutable, guaranteeing the faithful production of saturated fatty acids, in the modular polyketide synthases, the potential of the basic design has been exploited to the full for the elaboration of a wide range of secondary metabolites of extraordinary structural diversity.
本综述记录了上个世纪脂肪酸合成和聚酮化合物合成领域的协同发展。在动物脂肪酸合成酶和模块化聚酮化合物合成酶中,相似的催化元件在大型合成酶中以相同顺序共价连接。在脂肪酸合成酶中,设计的基本元件保持不变,确保饱和脂肪酸的稳定生成;而在模块化聚酮化合物合成酶中,基本设计的潜力得到了充分利用,用于合成各种结构多样的次生代谢产物。