Gao Jin-Ming, Wu Wen-Jun, Zhang Ji-Wen, Konishi Yasuo
College of Sciences, Northwest A & F University, Yangling, Shaanxi 712100, China.
Nat Prod Rep. 2007 Oct;24(5):1153-89. doi: 10.1039/b601473a. Epub 2007 May 1.
Dihydro-Beta-agarofuran sesquiterpenoids are a structurally diverse class of natural products based on tricyclic 5,11-epoxy-5Beta,10alpha-eudesman-4-(14)-ene skeleton. Between January 1990 and June 2006, 462 new dihydro-Beta-agarofuran sesquiterpenoids of 74 structural types have been isolated from about 64 species of Celastraceae, 3 species of Hippocrateaceae and one species of Lamiaceae. The present review covers the chemical and biological activity research of dihydro-Beta-agarofuran sesquiterpenoids in the past 16 years. The chemical research includes structural classification into sesquiterpene polyesters and macrolide sesquiterpene pyridine alkaloids, synthesis of dihydro-Beta-agarofuran as well as extraction, isolation and purification methods. The biological activity research includes activities such as multidrug resistance (MDR) reversal activity, HIV inhibition, cytotoxicity, antitumor activity, antifeedant activity and insecticidal activity with some insights to their modes of actions.
二氢-β-agarofuran倍半萜类化合物是一类结构多样的天然产物,其基于三环5,11-环氧-5β,10α-桉叶-4-(14)-烯骨架。在1990年1月至2006年6月期间,已从约64种卫矛科植物、3种希氏藤科植物和1种唇形科植物中分离出462种新的74种结构类型的二氢-β-agarofuran倍半萜类化合物。本综述涵盖了过去16年中二氢-β-agarofuran倍半萜类化合物的化学和生物活性研究。化学研究包括倍半萜聚酯和大环倍半萜吡啶生物碱的结构分类、二氢-β-agarofuran的合成以及提取、分离和纯化方法。生物活性研究包括多药耐药性(MDR)逆转活性、HIV抑制、细胞毒性、抗肿瘤活性、拒食活性和杀虫活性等,并对其作用方式有一些见解。