来自托氏十字花瓣木的新型倍半萜的抗肿瘤促进作用。

Antitumor-promoting effects of new sesquiterpenes from Crossopetalum tonduzii.

作者信息

Mendoza Cristina R, Jiménez Ignacio A, Tokuda Harukuni, Kushida Hiroyuki, Bazzocchi Isabel L

机构信息

Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, La Laguna, 38206 Tenerife.

出版信息

Chem Biodivers. 2005 Feb;2(2):286-94. doi: 10.1002/cbdv.200590011.

DOI:10.1002/cbdv.200590011

PMID:17191981

Abstract

Seven new sesquiterpenes (1-7) with a 'dihydro-beta-agarofuran' (= 5,11-epoxy-5beta,10alpha-eudesmane) skeleton were isolated from Crossopetalum tonduzii. Their structures were elucidated spectroscopically, especially by means of homo- and heteronuclear NMR correlation (COSY, ROESY, HSQC, and HMBC). The absolute configurations of the new compounds were determined by circular dichroism (CD) studies and by chemical correlations via the derivatives 8-11. The new compounds showed moderate antitumor-promoting effects with respect to the activation of the Epstein-Barr virus early antigen (EBV-EA).

摘要

从托氏十字瓣木（Crossopetalum tonduzii）中分离出了七种具有“二氢-β-琼脂呋喃”（= 5,11-环氧-5β,10α-桉叶烷）骨架的新倍半萜（1-7）。通过光谱法，特别是通过同核和异核NMR相关（COSY、ROESY、HSQC和HMBC）阐明了它们的结构。通过圆二色性（CD）研究以及经由衍生物8-11的化学关联确定了新化合物的绝对构型。就爱泼斯坦-巴尔病毒早期抗原（EBV-EA）的激活而言，新化合物显示出中等的抗肿瘤促进作用。