Raaijmaakers Martijn, Steenbrugge Franky, Dierickx Carl
Department of Orthopaedic Surgery and Traumatology, Algemeen Stedelijk Ziekenhuis, Merestraat 80, 9300, Aalst, Belgium.
Knee Surg Sports Traumatol Arthrosc. 2008 Feb;16(2):182-4. doi: 10.1007/s00167-007-0413-x. Epub 2007 Sep 25.
Ochronotic arthropathy is a rare condition found in patients with alkaptonuria. Due to the accumulation of homogentisic acid, cartilages get a dark discoloration and become brittle and more vulnerable to mechanical stress (Centinus et al. Rheumatol Int 3:127-131, 2004; Hamdi et al. Int Orthop 23:122-125, 1999; Phornphutkul, N Engl J Med 347:2111-2121, 2002; Thacker, Arthroscopy 19:14-17, 2003). This case report is about a patient first diagnosed for ochronosis by arthroscopy of the knee. Her brother was having similar complaints during follow-up. Both patients were prescribed to take glucosamine and chondroitine. Although no report is found in the literature, regarding the success of this therapy in patients with ochronosis, both patients reported a positive effect on articular pain and daily activities.
褐黄病性关节病是一种在患尿黑酸尿症的患者中发现的罕见病症。由于尿黑酸的积累，软骨会出现深色变色，并变得脆弱，更容易受到机械应力的影响（Centinus等人，《国际风湿病学》3:127 - 131，2004年；Hamdi等人，《国际骨科学杂志》23:122 - 125，1999年；Phornphutkul，《新英格兰医学杂志》347:2111 - 2121，2002年；Thacker，《关节镜检查》19:14 - 17，2003年）。本病例报告是关于一名通过膝关节镜检查首次被诊断为褐黄病的患者。在随访期间，她哥哥也有类似症状。两名患者均被开了氨基葡萄糖和软骨素。尽管文献中未发现关于该疗法对褐黄病患者疗效的报道，但两名患者均称该疗法对关节疼痛和日常活动有积极效果。
