Carrier D A, Harris C M
Department of Surgery, University of Rochester School of Medicine and Dentistry, New York.
Orthop Rev. 1990 Nov;19(11):1005-9.
Alkaptonuria is a rare, autosomal-recessive, inborn, metabolic disease that causes ochronotic arthropathy leading to disabling arthritis. Few reports of arthroplasty in patients with this disease have been published, and none documents four total joint replacements in the same patient. This case report describes the history and findings in a 70-year-old man who underwent bilateral hip and knee total joint arthroplasties with significant improvement in pain and exercise tolerance. The metabolic and clinical aspects of alkaptonuria are also discussed.
黑尿症是一种罕见的常染色体隐性先天性代谢疾病，可导致褐黄病性关节病，进而发展为致残性关节炎。关于该病患者关节置换术的报道较少，且尚无同一患者接受四次全关节置换的文献记载。本病例报告描述了一名70岁男性患者的病史及检查结果，该患者接受了双侧髋关节和膝关节全关节置换术，术后疼痛和运动耐量显著改善。文中还讨论了黑尿症的代谢及临床方面的情况。
