Weinstein Aviv, Brickner Orit, Lerman Hedva, Greemland Mazal, Bloch Miki, Lester Hava, Chisin Roland, Mechoulam Raphael, Bar-Hamburger Rachel, Freedman Nanette, Even-Sapir Einat
Department of Nuclear Medicine, Sourasky Medical Center, Tel Aviv, Israel.
Psychopharmacology (Berl). 2008 Jan;196(1):119-31. doi: 10.1007/s00213-007-0940-7. Epub 2007 Sep 26.
Twelve regular users of marijuana underwent two positron emission tomography (PET) scans using [18F] Fluorodeoxyglucose (FDG), one while subject to the effects of 17 mg THC, the other without THC. In both sessions, a virtual reality maze task was performed during the FDG uptake period.
When subject to the effects of 17 mg THC, regular marijuana smokers hit the walls more often on the virtual maze task than without THC. Compared to results without THC, 17 mg THC increased brain metabolism during task performance in areas that are associated with motor coordination and attention in the middle and medial frontal cortices and anterior cingulate, and reduced metabolism in areas that are related to visual integration of motion in the occipital lobes.
These findings suggest that in regular marijuana users, the immediate effects of marijuana may impact on cognitive-motor skills and brain mechanisms that modulate coordinated movement and driving.
12名大麻经常使用者使用[18F]氟脱氧葡萄糖（FDG）进行了两次正电子发射断层扫描（PET），一次是在受17毫克四氢大麻酚影响时，另一次是未受四氢大麻酚影响时。在这两个阶段中，在FDG摄取期间进行了虚拟现实迷宫任务。
在受17毫克四氢大麻酚影响时，经常吸食大麻的人在虚拟迷宫任务中比未受四氢大麻酚影响时更频繁地撞到墙壁。与未受四氢大麻酚影响时的结果相比，17毫克四氢大麻酚在任务执行期间增加了与中额叶和内侧额叶皮质以及前扣带回中的运动协调和注意力相关区域的大脑代谢，并降低了枕叶中与运动视觉整合相关区域的代谢。
这些发现表明，在经常使用大麻的人中，大麻的即时效应可能会影响调节协调运动和驾驶的认知运动技能和脑机制。
