任务相关脑活动评估：FDG-PET 成像是否有作用？
Evaluation of Task-Related Brain Activity: Is There a Role for F FDG-PET Imaging?
机构信息
Department of Biomedicine and Prevention, Faculty of Medicine and Surgery, Tor Vergata University, Rome, Italy.
IRCCS Neuromed, UOC Medicina Nucleare, Pozzilli (IS), Italy.
出版信息
Biomed Res Int. 2019 Jul 2;2019:4762404. doi: 10.1155/2019/4762404. eCollection 2019.
Positron emission tomography (PET) with 2-[18F]-fluorodeoxyglucose (FDG) has been widely used for the evaluation of cortical glucose metabolism in several neurodegenerative disorders while its potential role in the evaluation of cortical and subcortical activity during a task in the healthy and pathological brain still remains to be a matter of debate. Few studies have been carried out in order to investigate the potential role of this radiotracer for the evaluation of brain glucose consumption during dynamic brain activation. The aim of this review is to provide a general overview of the applications of FDG-PET in the evaluation of cortical activation at rest and during tasks, describing first the physiological basis of FDG distribution in brain and its kinetic in vivo. An overview of the imaging protocols and image interpretation will be provided as well. As a last aspect, the results of the main studies in this field will be summarized and the results of PET findings performed in healthy subjects and patients suffering from various diseases will be reported.
正电子发射断层扫描（PET）结合 2-[18F]-氟代脱氧葡萄糖（FDG）已广泛用于评估几种神经退行性疾病的皮质葡萄糖代谢，但其在评估健康和病理大脑在任务期间皮质和皮质下活动中的潜在作用仍存在争议。为了研究这种放射性示踪剂在评估动态脑激活期间脑葡萄糖消耗中的潜在作用，已经进行了一些研究。本综述的目的是提供 FDG-PET 在评估静息和任务期间皮质激活中的应用的概述，首先描述 FDG 在大脑中的分布的生理基础及其在体内的动力学。还将提供成像方案和图像解释的概述。作为最后一个方面，将总结该领域主要研究的结果，并报告在健康受试者和患有各种疾病的患者中进行的 PET 研究结果。
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